Detailed information of TA system TA021157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3546030..3546664
• Replicon: chromosome
• Accession: NC_006513
• Organism: Aromatoleum aromaticum EbN1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EB_RS16710
• Protein ID: WP_011239195.1
• Coordinates: 3546263..3546664 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5NZI0
• Locus tag: EB_RS16705
• Protein ID: WP_011239194.1
• Coordinates: 3546030..3546263 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB_RS16670	3541039..3541326	+	288	WP_041646540.1	DUF1778 domain-containing protein	-
EB_RS23440	3541311..3541814	+	504	WP_197531824.1	GNAT family N-acetyltransferase	-
EB_RS16675	3541898..3542188	+	291	WP_011239187.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EB_RS16680	3542188..3542625	+	438	WP_011239188.1	putative toxin-antitoxin system toxin component, PIN family	-
EB_RS16685	3542831..3543169	+	339	WP_011239189.1	H-NS histone family protein	-
EB_RS16690	3543355..3543606	+	252	WP_011239190.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EB_RS16695	3543515..3543922	+	408	Protein_3311	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
EB_RS16700	3544406..3545956	+	1551	WP_011239193.1	O-antigen ligase family protein	-
EB_RS16705	3546030..3546263	+	234	WP_011239194.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EB_RS16710	3546263..3546664	+	402	WP_011239195.1	tRNA(fMet)-specific endonuclease VapC	Toxin
EB_RS16720	3546871..3549459	-	2589	WP_011239196.1	[protein-PII] uridylyltransferase	-
EB_RS16725	3549466..3550287	-	822	WP_011239197.1	type I methionyl aminopeptidase	-
EB_RS16730	3550657..3551412	+	756	WP_011239199.1	30S ribosomal protein S2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14679.98 Da
• Isoelectric Point: 8.9537

>T21157 WP_011239195.1 NC_006513:3546263-3546664 [Aromatoleum aromaticum EbN1]
MLRYLLDTNIVIYVIKRRPLSALALFNVNAGHMAISSITLAELMHGAEKSNAPARSLAAVEDFCSRLEVLPYGPKAAMHY
GNIRARLESRGQTIGVNDLHIAAHARSEGLTLVSNNLREFERVEALQLANWAI

Nucleotide

• Length: 402 bp

>T21157 NC_006513:3546263-3546664 [Aromatoleum aromaticum EbN1]
ATGCTGCGCTATCTGCTCGATACGAACATCGTGATCTACGTGATCAAGCGCCGGCCACTGTCGGCATTGGCGCTGTTCAA
CGTGAACGCGGGACATATGGCGATCTCCTCGATCACCCTCGCGGAGCTGATGCACGGCGCCGAGAAAAGCAATGCGCCGG
CGCGTTCGCTTGCCGCCGTGGAGGATTTTTGCAGCCGCCTCGAGGTGCTGCCATACGGTCCGAAAGCCGCAATGCACTAT
GGCAACATCCGTGCTCGACTCGAGTCTCGCGGTCAGACGATCGGTGTCAATGACCTGCACATCGCAGCCCACGCACGCAG
CGAGGGTCTGACGCTCGTGTCGAACAACTTGCGCGAGTTCGAGCGGGTGGAAGCATTGCAACTGGCGAACTGGGCAATCT
GA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8745.83 Da
• Isoelectric Point: 5.0022

>AT21157 WP_011239194.1 NC_006513:3546030-3546263 [Aromatoleum aromaticum EbN1]
MTTTTVFTNNRSQAVRLPADMRLPANVKQVDIRARGLERIIAPVGHTWDSFFIDGPQVADDFMETRASQEQQEREAL

Nucleotide

• Length: 234 bp

>AT21157 NC_006513:3546030-3546263 [Aromatoleum aromaticum EbN1]
ATGACCACAACCACCGTCTTCACGAACAATCGCAGCCAGGCCGTGCGACTGCCGGCAGACATGCGCTTGCCCGCGAACGT
CAAGCAAGTGGACATCCGCGCTCGCGGGTTGGAGCGAATCATCGCGCCGGTGGGCCATACGTGGGATTCGTTCTTCATCG
ATGGGCCGCAGGTTGCCGACGATTTCATGGAAACCCGCGCCAGCCAGGAACAGCAGGAACGCGAAGCCCTCTGA

Structures

Antitoxin

• AlphaFold DB: Q5NZI0