Detailed information of TA system TA211568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 5651960..5652601
• Replicon: chromosome
• Accession: NZ_CP080274
• Organism: Mycolicibacterium smegmatis strain Jucho

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: KZ780_RS26860
• Protein ID: WP_011730672.1
• Coordinates: 5651960..5652403 (-)
• Length: 148 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: I7FKW8
• Locus tag: KZ780_RS26865
• Protein ID: WP_011730673.1
• Coordinates: 5652413..5652601 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ780_RS26840 (KZ780_26705)	5647443..5648180	+	738	WP_011730668.1	GntR family transcriptional regulator	-
KZ780_RS26845 (KZ780_26710)	5648182..5649714	+	1533	WP_011730669.1	cyclohexanecarboxylate-CoA ligase	-
KZ780_RS26850 (KZ780_26715)	5649715..5650488	+	774	WP_011730670.1	SDR family oxidoreductase	-
KZ780_RS26855 (KZ780_26720)	5650485..5651957	+	1473	WP_011730671.1	long-chain fatty acid--CoA ligase	-
KZ780_RS26860 (KZ780_26725)	5651960..5652403	-	444	WP_011730672.1	SRPBCC family protein	Toxin
KZ780_RS26865 (KZ780_26730)	5652413..5652601	-	189	WP_011730673.1	antitoxin	Antitoxin
KZ780_RS26870 (KZ780_26735)	5652627..5655002	-	2376	WP_011730674.1	cation-translocating P-type ATPase	-
KZ780_RS26875 (KZ780_26740)	5655016..5656623	-	1608	WP_162139558.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-141)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 148 a.a.
• Molecular weight: 16157.75 Da
• Isoelectric Point: 9.9432

>T211568 WP_011730672.1 NZ_CP080274:c5652403-5651960 [Mycolicibacterium smegmatis]
MAKLSVSVEVPLPPEQAWEYASDLSRYHEWLSIHRAWRSKLPETLEKGTVIESIVEVKGMLNRVRWTLVHYKPPQALTLN
GDGRGGVKVKLIGKIKPTDNGATVGFDLHLGGPALFGPIGMVVAAALKSDIQESLNRFKQLYAPSAT

Nucleotide

• Length: 444 bp

>T211568 NZ_CP104967:c89233-88328 [Phyllobacterium sp. A18/5-2]
ATGGCGGGTGAACCGAAGAAAAATGTCGGGGCATCGGTGCGCGCCCGGCTCCTGGATCGGTCTCGCGCGGAACGCACGGA
CTTTCAGATCCTGTTGACGCGCTATGCGCTCGAAAGGTTCCTGTACCGGCTGAGCCTATCCGCGCATCGCGACCGCTTCA
TCCTCAAGGGCGCGATGCTGTTCGTTGCCTGGGTCGCCGACCCTTTTCGGCCAACGCGGGACCTCGACCTGCTGGGGTAC
GGCGAGAACAGTCCTAGGGCCATCGCAGAGACTTTCCACGCTATTTGCACACAGCCGGTCGAGGATGACGGTGTTGTCTT
CGACCTGGACGGGCTCGAAGCCGCGCCGATCCGAGAAGAAGTCGAGTATGGCGGCGTTCGCGTCCGCACCACGGCCACCA
TCGCAGGCGCCCGCATTCCGATCCAGGTGGACATAGGCTTCGGCGACGCCGTCACCCCGGGACCGGTCGATATAGAATAT
CCATCGTTGCTCGATGCGCCGGCGCCGCGCCTTCGAGCTTATCCGGTCGCAACCGTGATCGCCGAGAAATTCGAGGCGCT
GGTGACACTCGGCATGGCGAATAGCCGCCTGAAGGATTTCTACGATCTTTGGCTGATCGCCGAAACGTTCGAGCTTGAGC
GGTCCACCCTCGCGGAGGCCGCGCGCCAGACTTTCGCTAGAAGAGGGACAGATTTTCGGAAGGAGAGGCCGATGGGTCTC
AGTGATGCCTACGCCGAAGTGTGGGATCGGCAATGGCGGGCGTTTCTCGGACGCGAACGTATGGCCGCTGCGCCGCCACG
TCTGGCTGCTGTAGTGACGGACCTCGGGCGGCTTTTACTGCCCCTGATGGCGCAGACTGACGGCGATTGGCGTTGGAAGC
CGCGTGAGGGATGGATTCAATCGTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6867.59 Da
• Isoelectric Point: 4.6868

>AT211568 WP_011730673.1 NZ_CP080274:c5652601-5652413 [Mycolicibacterium smegmatis]
MGFLDKAKDLLSQNADKVDTVIDKAGDMIDEKTQGKYAQHVDKAQDAAKNAIHKDDPQEPQQ

Nucleotide

• Length: 189 bp

>AT211568 NZ_CP104967:c89786-89223 [Phyllobacterium sp. A18/5-2]
ATGCTGCGGCTGAAGGATTTCGCCGCGCACGGCATTGGCTCAGAGACGCTCGCGCGTCTCGTACGAGATGAAGAAGTCGT
TCGTCCGGCGCGCGGCCTCTACCAGCTTCCCGACGCTGCGGCCGACGCACGACATGTCCTGGCCGAGGCATCGGCGCTTG
TGCCGAAAGGGATCGTCTGCCTGACCTCGGCGCTGCAATTTCATGAGCTGACGCTGCAGATGCCGTCGGCGGTCTGGATG
GCCATCGATCGAACGGCTTGGCGCCCTAAGATCGACTATCCGCCTATCCGTTTCGTACGCTTCACCGGCGCCGCTCTCAC
CGAGGGCGTCGAACGGCATCGCATCGAGGGGGTCGAGGTGCCGATCACAAATCCGGCGCGCTCGATCGTCGATTGCTTCC
GCTATCGGACGAAAGTCGGCCTCGATGTTGCGATGGAGGGGCTGCGCGAGGGGCTCCGGCGGCGCAAGACCACAAGTGAC
GAACTCTGGGCTTATGCGAAGAGGGCCAGAATCTGGTCGACCATGCGACCCTATGTCGAAGCGACGGTGGCTGATGGCGG
GTGA

Structures

Antitoxin

• AlphaFold DB: A0A653F9V2