211565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1315740..1316383 Replicon chromosome
Accession NZ_CP080274
Organism Mycolicibacterium smegmatis strain Jucho

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4QHE7
Locus tag KZ780_RS06030 Protein ID WP_011727564.1
Coordinates 1315994..1316383 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag KZ780_RS06025 Protein ID WP_003892665.1
Coordinates 1315740..1315994 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ780_RS06015 (KZ780_05960) 1311170..1314553 + 3384 WP_038557635.1 ATP-binding protein -
KZ780_RS06020 (KZ780_05965) 1314550..1315719 + 1170 WP_011727563.1 DUF3322 and DUF2220 domain-containing protein -
KZ780_RS06025 (KZ780_05970) 1315740..1315994 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KZ780_RS06030 (KZ780_05975) 1315994..1316383 + 390 WP_011727564.1 type II toxin-antitoxin system VapC family toxin Toxin
KZ780_RS06035 (KZ780_05980) 1316402..1318807 - 2406 WP_239779584.1 SEC-C metal-binding domain-containing protein -
KZ780_RS06040 (KZ780_05985) 1318829..1320589 - 1761 WP_239779585.1 sulfatase-like hydrolase/transferase -
KZ780_RS06045 (KZ780_05990) 1320586..1321023 - 438 WP_011727567.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13909.73 Da        Isoelectric Point: 4.7222

>T211565 WP_011727564.1 NZ_CP080274:1315994-1316383 [Mycolicibacterium smegmatis]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEAFRLTDVAAVH

Download         Length: 390 bp

>T211565 NZ_CP104966:c2596412-2596137 [Phyllobacterium sp. A18/5-2]
GTGCCGGTTCTTGAATGGCGCGAAACAGCGCGAGCCGACTTGTTGGCAATTATGGATTATATCTCGGATGATAGTCCGGC
GGCGGCACAGCAATTAAAGAATGAAATCGAAATGAAGGTACTTAATTTATTAAAGTACCCTCGCTCCTGTAAACTTGGTC
GAGTTCCAGGAACACGTGAAATGATCGTCAGGGCCAACTATATATTGATCTATACCGAGAACGTTCAAGCTGTCTCGATT
TTACGTGTTCTCCATGCCGCGCAGCAGTGGCCGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT211565 WP_003892665.1 NZ_CP080274:1315740-1315994 [Mycolicibacterium smegmatis]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp

>AT211565 NZ_CP104966:c2596704-2596399 [Phyllobacterium sp. A18/5-2]
ATGGCCACTCATACTTCGATGCTGCATGTACGAATCGACAATAAGCTGAAAGCGCAGGCGACCGAAACACTTGGTCAATT
CGGTTTGACCGTGTCAGATGCTGTTCGAATTCTTCTGACCCGTATTGCGAATGACCAAGCATTGCCAGTCGGTCTTATTG
CCGATCAAGAAACATACGACAAATGGTTTCGTCAAAAGGTCCAGGAGGCATTGGACGATCAACGCCACCCAGCAATCCAG
CATGACGACGTTATGGACGAAATTCAAACCATGATTGATAGAAAACGCCATCGTGCCGGTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHE7

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References