211564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 1308509..1309095 Replicon chromosome
Accession NZ_CP080274
Organism Mycolicibacterium smegmatis strain Jucho

Toxin (Protein)


Gene name doc Uniprot ID A0A8B4QHV5
Locus tag KZ780_RS06000 Protein ID WP_011727560.1
Coordinates 1308703..1309095 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2U9PKT9
Locus tag KZ780_RS05995 Protein ID WP_011727559.1
Coordinates 1308509..1308706 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ780_RS05970 (KZ780_05915) 1303542..1305020 - 1479 WP_239779609.1 ADP-ribosylglycohydrolase family protein -
KZ780_RS05975 (KZ780_05920) 1305209..1305550 - 342 WP_011727555.1 DUF732 domain-containing protein -
KZ780_RS05980 (KZ780_05925) 1305610..1306683 - 1074 WP_228025495.1 SMP-30/gluconolactonase/LRE family protein -
KZ780_RS05985 (KZ780_05930) 1306918..1307997 - 1080 WP_011727557.1 HNH endonuclease domain-containing protein -
KZ780_RS05990 (KZ780_05935) 1308065..1308361 + 297 WP_003892658.1 nucleoside triphosphate pyrophosphohydrolase -
KZ780_RS05995 (KZ780_05940) 1308509..1308706 + 198 WP_011727559.1 type II toxin-antitoxin system antitoxin Phd Antitoxin
KZ780_RS06000 (KZ780_05945) 1308703..1309095 + 393 WP_011727560.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KZ780_RS06005 (KZ780_05950) 1309172..1310602 + 1431 WP_003892661.1 DUF3375 domain-containing protein -
KZ780_RS06010 (KZ780_05955) 1310599..1311177 + 579 WP_038557632.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(49-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13939.57 Da        Isoelectric Point: 4.2481

>T211564 WP_011727560.1 NZ_CP080274:1308703-1309095 [Mycolicibacterium smegmatis]
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAAQTG

Download         Length: 393 bp

>T211564 NZ_CP104966:c1784004-1783741 [Phyllobacterium sp. A18/5-2]
ATGCTGTTTGAGTACGATCCGGCAAAGAGCGCGTCCAATAAAATCAAACACGGTATTGATTTTGAGGAAGCACAACCGCT
CTGGAAAGAAGACCGGATGCTGGAAGCTCCAGCCAAAGTGGACGGAGAGCCGCGTTTTCTCGTAATTGGCTTACTCAGAG
GCAAACATTGGTCAGCTATCTGCGTTTACAGAAGCGGTAAGGTTCGCATCATTTCGGTTCGCCGGGCCCGAAAACAGGAA
ATCGAATACTATGAAGACAAGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7276.30 Da        Isoelectric Point: 8.9353

>AT211564 WP_011727559.1 NZ_CP080274:1308509-1308706 [Mycolicibacterium smegmatis]
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA

Download         Length: 198 bp

>AT211564 NZ_CP104966:c1783754-1783539 [Phyllobacterium sp. A18/5-2]
ATGAAGACAAGTGATTTTGACCGCAATTTCGACGAGGGAGAAGATATTGCCGAACAGGTGGATTGGTCGAAGGCCCGTCG
GCCCAACGAAGAACTCAAGCGGGTGAATGTCGACTTTCCCATGTGGGTAGTGGAAGGTCTGGACAGACAGGCACGGCGGC
TTGGCGTGACCAGACAAGCCCTTATCAAGCTCTGGATCGCCGAACGACTGGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHV5

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PKT9

References