Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4706736..4707433 Replicon chromosome
Accession NZ_CP080273
Organism Mycolicibacterium smegmatis strain Nishi

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ781_RS22305 Protein ID WP_081319354.1
Coordinates 4707002..4707433 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ781_RS22300 Protein ID WP_058125156.1
Coordinates 4706736..4706993 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ781_RS22285 (KZ781_22125) 4702226..4703782 - 1557 WP_058125158.1 type VII secretion protein EccB -
KZ781_RS22290 (KZ781_22130) 4703779..4705548 - 1770 WP_058125157.1 type VII secretion AAA-ATPase EccA -
KZ781_RS22295 (KZ781_22135) 4705735..4706637 - 903 WP_058127516.1 class I SAM-dependent methyltransferase -
KZ781_RS22300 (KZ781_22140) 4706736..4706993 + 258 WP_058125156.1 ribbon-helix-helix protein, CopG family Antitoxin
KZ781_RS22305 (KZ781_22145) 4707002..4707433 + 432 WP_081319354.1 type II toxin-antitoxin system VapC family toxin Toxin
KZ781_RS22310 (KZ781_22150) 4707445..4708350 - 906 WP_058125154.1 oxygenase MpaB family protein -
KZ781_RS22315 (KZ781_22155) 4708429..4709061 + 633 WP_058125153.1 TetR/AcrR family transcriptional regulator -
KZ781_RS22320 (KZ781_22160) 4709118..4710509 - 1392 WP_058125152.1 carboxylesterase family protein -
KZ781_RS22325 (KZ781_22165) 4710502..4711410 - 909 WP_058125151.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15939.08 Da        Isoelectric Point: 6.1461

>T211562 WP_081319354.1 NZ_CP080273:4707002-4707433 [Mycolicibacterium smegmatis]
MFLLDVNVVLAAYRADHPDHATVRPWFDRLLDGDGPFTVPVQVWASFLRLVTNRRIFPVPTPRDDAFAFIEAVNGQPHHV
PVSAGPRHLALLHQLCDEGDASGDLIPDAVLAAIAHEHHCDVATLDRDFARFTTVRHLRPSLD

Download         Length: 432 bp

>T211562 NZ_CP104965:1725786-1726217 [Devosia neptuniae]
GTGAGTTTCCTGCTCGATACCAATGTGCTGTCCGAGATACGCCGGCCGCAGCCGGATCAGCAGGTGCTGACCTGGCTCGA
CCAGGTGGATGAGGACCGCACCTATCTCAGCGTCATCACCATTGCCGAGATTGCGCGCGGTGTGGCGCTGATGGATGACG
GCCGGCGCCGGAACGAGCTGGCGCAATGGCTCGAGCTGGATCTGCCGGCCCGATTCGGCGATCGCATCCTGCCCGTGGAT
ACGCAGATCGCGCTGATCTGGGGCAAGCTGCTCGCCTCGACCCGCAAAGAGGGGATTGGCCTGAGCGTCATGGATGGCTG
GATCGCCGCCACGGCCATTGCCCTTCAGCTGGTTTTGGTGACCCGTAATACCAGGGATTTCGAGAATCTCCCGCTGACCT
TGCTCGATCCGTGGTCGCCGCCGGCAGCGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9140.34 Da        Isoelectric Point: 5.8508

>AT211562 WP_058125156.1 NZ_CP080273:4706736-4706993 [Mycolicibacterium smegmatis]
VRTTIAIADELLAAAKRRARQRGQSLGSVIEDALRRELAADQEAAPRPEVPVFTDGTGPRAGIDLRSARALHEVLDEGLD
LNALK

Download         Length: 258 bp

>AT211562 NZ_CP104965:1725526-1725789 [Devosia neptuniae]
ATGTCCGCGACCAAGAAGCAGGAGGCCTGGACCGTGGCCAATGCCAAGGCGCATTTGTCCGAGGTTATCGAGCGCGCCCA
GAGTGAGCCGCAGATGATCACGCGCAATGGTACGCCCAGCGTGGTGATCGTGTCGGTGGAAGAATGGAACCGCAAGACCG
AGCGCAAGGGGAGCCTGGCGACGTTCCTTTTGAGCTCGCCCTTGGCGGGGACGGAGCTAGCCGATGCGCGCCTGCTCGAT
GAGCCGCGCGATCTGGCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References