Detailed information of TA system TA211562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4706736..4707433
• Replicon: chromosome
• Accession: NZ_CP080273
• Organism: Mycolicibacterium smegmatis strain Nishi

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KZ781_RS22305
• Protein ID: WP_081319354.1
• Coordinates: 4707002..4707433 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KZ781_RS22300
• Protein ID: WP_058125156.1
• Coordinates: 4706736..4706993 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ781_RS22285 (KZ781_22125)	4702226..4703782	-	1557	WP_058125158.1	type VII secretion protein EccB	-
KZ781_RS22290 (KZ781_22130)	4703779..4705548	-	1770	WP_058125157.1	type VII secretion AAA-ATPase EccA	-
KZ781_RS22295 (KZ781_22135)	4705735..4706637	-	903	WP_058127516.1	class I SAM-dependent methyltransferase	-
KZ781_RS22300 (KZ781_22140)	4706736..4706993	+	258	WP_058125156.1	ribbon-helix-helix protein, CopG family	Antitoxin
KZ781_RS22305 (KZ781_22145)	4707002..4707433	+	432	WP_081319354.1	type II toxin-antitoxin system VapC family toxin	Toxin
KZ781_RS22310 (KZ781_22150)	4707445..4708350	-	906	WP_058125154.1	oxygenase MpaB family protein	-
KZ781_RS22315 (KZ781_22155)	4708429..4709061	+	633	WP_058125153.1	TetR/AcrR family transcriptional regulator	-
KZ781_RS22320 (KZ781_22160)	4709118..4710509	-	1392	WP_058125152.1	carboxylesterase family protein	-
KZ781_RS22325 (KZ781_22165)	4710502..4711410	-	909	WP_058125151.1	MBL fold metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-132)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-39)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15939.08 Da
• Isoelectric Point: 6.1461

>T211562 WP_081319354.1 NZ_CP080273:4707002-4707433 [Mycolicibacterium smegmatis]
MFLLDVNVVLAAYRADHPDHATVRPWFDRLLDGDGPFTVPVQVWASFLRLVTNRRIFPVPTPRDDAFAFIEAVNGQPHHV
PVSAGPRHLALLHQLCDEGDASGDLIPDAVLAAIAHEHHCDVATLDRDFARFTTVRHLRPSLD

Nucleotide

• Length: 432 bp

>T211562 NZ_CP104965:1725786-1726217 [Devosia neptuniae]
GTGAGTTTCCTGCTCGATACCAATGTGCTGTCCGAGATACGCCGGCCGCAGCCGGATCAGCAGGTGCTGACCTGGCTCGA
CCAGGTGGATGAGGACCGCACCTATCTCAGCGTCATCACCATTGCCGAGATTGCGCGCGGTGTGGCGCTGATGGATGACG
GCCGGCGCCGGAACGAGCTGGCGCAATGGCTCGAGCTGGATCTGCCGGCCCGATTCGGCGATCGCATCCTGCCCGTGGAT
ACGCAGATCGCGCTGATCTGGGGCAAGCTGCTCGCCTCGACCCGCAAAGAGGGGATTGGCCTGAGCGTCATGGATGGCTG
GATCGCCGCCACGGCCATTGCCCTTCAGCTGGTTTTGGTGACCCGTAATACCAGGGATTTCGAGAATCTCCCGCTGACCT
TGCTCGATCCGTGGTCGCCGCCGGCAGCGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9140.34 Da
• Isoelectric Point: 5.8508

>AT211562 WP_058125156.1 NZ_CP080273:4706736-4706993 [Mycolicibacterium smegmatis]
VRTTIAIADELLAAAKRRARQRGQSLGSVIEDALRRELAADQEAAPRPEVPVFTDGTGPRAGIDLRSARALHEVLDEGLD
LNALK

Nucleotide

• Length: 258 bp

>AT211562 NZ_CP104965:1725526-1725789 [Devosia neptuniae]
ATGTCCGCGACCAAGAAGCAGGAGGCCTGGACCGTGGCCAATGCCAAGGCGCATTTGTCCGAGGTTATCGAGCGCGCCCA
GAGTGAGCCGCAGATGATCACGCGCAATGGTACGCCCAGCGTGGTGATCGTGTCGGTGGAAGAATGGAACCGCAAGACCG
AGCGCAAGGGGAGCCTGGCGACGTTCCTTTTGAGCTCGCCCTTGGCGGGGACGGAGCTAGCCGATGCGCGCCTGCTCGAT
GAGCCGCGCGATCTGGCGCTGTGA