Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3271040..3272036 Replicon chromosome
Accession NZ_CP080273
Organism Mycolicibacterium smegmatis strain Nishi

Toxin (Protein)


Gene name pezT Uniprot ID A0A2U9PRH2
Locus tag KZ781_RS15585 Protein ID WP_003894880.1
Coordinates 3271458..3272036 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID I7GB97
Locus tag KZ781_RS15580 Protein ID WP_003894879.1
Coordinates 3271040..3271432 (+) Length 131 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ781_RS15560 (KZ781_15430) 3266511..3267629 + 1119 WP_003894875.1 acyltransferase -
KZ781_RS15565 (KZ781_15435) 3267802..3268407 + 606 WP_003894876.1 class I SAM-dependent methyltransferase -
KZ781_RS15570 (KZ781_15440) 3268409..3270037 - 1629 WP_239708700.1 GMC family oxidoreductase N-terminal domain-containing protein -
KZ781_RS15575 (KZ781_15445) 3270347..3270976 + 630 WP_003894878.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
KZ781_RS15580 (KZ781_15450) 3271040..3271432 + 393 WP_003894879.1 ParD-like family protein Antitoxin
KZ781_RS15585 (KZ781_15455) 3271458..3272036 + 579 WP_003894880.1 zeta toxin family protein Toxin
KZ781_RS15590 (KZ781_15460) 3272048..3273400 - 1353 WP_003894881.1 alpha/beta hydrolase-fold protein -
KZ781_RS15595 (KZ781_15465) 3273735..3273890 + 156 WP_003894882.1 hypothetical protein -
KZ781_RS15600 (KZ781_15470) 3274088..3275476 + 1389 WP_233045776.1 L-serine ammonia-lyase -
KZ781_RS15605 (KZ781_15475) 3275510..3276070 - 561 WP_058126281.1 hypothetical protein -
KZ781_RS15610 (KZ781_15480) 3276230..3277036 + 807 WP_239708701.1 transporter substrate-binding domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21119.30 Da        Isoelectric Point: 9.5596

>T211560 WP_003894880.1 NZ_CP080273:3271458-3272036 [Mycolicibacterium smegmatis]
VKRLDLVVGPNGAGKSTFVELTLAPLLTGSAFVNADEIAKRRWPHAPAEHSYDAARIASDTRLKLIELGESFIAETVFSH
PSKIELIDTAQAAGYTVVMHVVMIPEDLAVLRVQHRVRAGGHHVPEEKIRERHQRLWPLVALAAARADISTFYDNSAVRG
PRIVAQLAGGFAVGRPAWPMWAPQVLTSRWPE

Download         Length: 579 bp

>T211560 NZ_CP104964:c471044-470763 [Devosia neptuniae]
TTGGCAAAGTCATTCAAGGGAATCCAGCTGCAGATCGTAGCGTCCGGCAAGGCGCCGAAGGGCTTCCCTACTGACGTTCT
GCAGGCGGCTCGCCGAAAGCTTTTCATGATCACCAATGCTGCCGCTCTTCAGGACTTGCTGATGCCGCCCGGCAATAAAC
TGGAGGCCTTGAAAGGAAATCGTTCCGGCCAACATTCCATCCGCATCAACGACCAGTGGCGCGTTTGCTTCCGTTGGTCA
AATGGCGCAGCTGAAGACATCGAAATCACCGACTACCACTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13841.29 Da        Isoelectric Point: 4.9246

>AT211560 WP_003894879.1 NZ_CP080273:3271040-3271432 [Mycolicibacterium smegmatis]
MTETADRVTRFAADLVESAAAEGARQSRSAKQQLDHWARVGRAVSSQHTAARRRVEAALAGDLALRDLTPEEGVVFNAEI
SAAIEENLAHTDYGQVLAGRGVTTVALDDDGAIVRYQPDGTTTVLAPAQR

Download         Length: 393 bp

>AT211560 NZ_CP104964:c470723-470412 [Devosia neptuniae]
ATGTCCTTGACCTTTGACCCGCCAATCCATCCTGGCGAGATTCTACGTGAAGAGTTTCTTGTGCCGCTTAATCTATCGGC
CGGTGCTCTTGCCAAGCGTGTCAGCGTTCCCCGTACGCGGATTGAGCGCATCGTGAAGGAGGAAACGCCGATCACGCCCG
ACACGGCTCTACGTCTGTCGCGCGTGCTAGGGACGACCGCTCAATTCTGGATGAACATGCAGTCCGCATACGATCTGGTG
CGAGCCGAACAGGCCCATTCGGAAGATCTCAATTTGATCGCACCACTAGACAGCCTCGCGAGGGCCAGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2U9PRH2


Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PRP8

References