Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3541039..3541814 Replicon chromosome
Accession NC_006513
Organism Aromatoleum aromaticum EbN1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag EB_RS23440 Protein ID WP_197531824.1
Coordinates 3541311..3541814 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag EB_RS16670 Protein ID WP_041646540.1
Coordinates 3541039..3541326 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB_RS16620 3537440..3537784 + 345 WP_011239177.1 DUF86 domain-containing protein -
EB_RS16625 3537774..3538160 - 387 WP_041646537.1 type II toxin-antitoxin system VapC family toxin -
EB_RS16630 3538157..3538405 - 249 WP_041646538.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EB_RS16635 3538575..3538910 + 336 WP_011239179.1 H-NS histone family protein -
EB_RS16640 3538891..3539370 + 480 WP_011239180.1 VanZ family protein -
EB_RS16645 3539385..3539651 + 267 WP_011239181.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
EB_RS16650 3539696..3540022 + 327 WP_041646539.1 type II toxin-antitoxin system RelE/ParE family toxin -
EB_RS16655 3540015..3540326 + 312 WP_011239183.1 helix-turn-helix domain-containing protein -
EB_RS22970 3540487..3540660 + 174 WP_197531823.1 hypothetical protein -
EB_RS16670 3541039..3541326 + 288 WP_041646540.1 DUF1778 domain-containing protein Antitoxin
EB_RS23440 3541311..3541814 + 504 WP_197531824.1 GNAT family N-acetyltransferase Toxin
EB_RS16675 3541898..3542188 + 291 WP_011239187.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EB_RS16680 3542188..3542625 + 438 WP_011239188.1 putative toxin-antitoxin system toxin component, PIN family -
EB_RS16685 3542831..3543169 + 339 WP_011239189.1 H-NS histone family protein -
EB_RS16690 3543355..3543606 + 252 WP_011239190.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EB_RS16695 3543515..3543922 + 408 Protein_3311 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
EB_RS16700 3544406..3545956 + 1551 WP_011239193.1 O-antigen ligase family protein -
EB_RS16705 3546030..3546263 + 234 WP_011239194.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
EB_RS16710 3546263..3546664 + 402 WP_011239195.1 tRNA(fMet)-specific endonuclease VapC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-149)

Antitoxin

Vibrio phage ICP1, Orf50

(13-87)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 17617.28 Da        Isoelectric Point: 8.2918

>T21156 WP_197531824.1 NC_006513:3541311-3541814 [Aromatoleum aromaticum EbN1]
VGQAVSLTAPEPLTAHHDTSAFACGVENLDHWLKQRALKNQASGASRTFVVCEGKRVLAYYALASSAVAAEAATGRLRRN
MPDPIPVVVLGRLAIDRSLQGGGIGRALVRDACLRVLAAADAIGIRGMIVHALSESARAFYERAGFDPSPLDPMTLMATI
ADLREGP

Download         Length: 504 bp

>T21156 NC_006513:3541311-3541814 [Aromatoleum aromaticum EbN1]
GTGGGACAAGCGGTGAGTCTGACCGCGCCAGAACCCTTGACTGCGCACCACGACACCAGCGCATTTGCCTGTGGCGTCGA
GAATCTGGATCACTGGCTCAAACAGCGCGCCCTGAAAAACCAGGCCAGCGGTGCGTCACGCACTTTTGTGGTTTGCGAAG
GCAAACGGGTGCTTGCCTACTACGCGCTGGCGTCCAGCGCGGTAGCAGCGGAAGCCGCCACAGGTCGCCTACGGCGCAAC
ATGCCCGATCCCATTCCGGTTGTGGTTCTGGGACGGCTTGCCATCGATCGATCGTTGCAGGGCGGCGGCATCGGTCGTGC
CCTGGTGCGTGATGCGTGTTTGCGCGTGCTTGCCGCAGCCGACGCCATTGGCATTCGTGGAATGATCGTTCATGCCTTGT
CGGAGAGCGCTCGGGCATTTTACGAGCGTGCCGGATTCGACCCGTCTCCCCTCGATCCCATGACTTTGATGGCCACCATT
GCCGATCTGCGCGAGGGGCCGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10703.27 Da        Isoelectric Point: 10.4623

>AT21156 WP_041646540.1 NC_006513:3541039-3541326 [Aromatoleum aromaticum EbN1]
MSAANSIAKRDTLNLRIKPEVRGLIDRAAKVRGKNRTDFILDAARNAAEEALLDQALFLVSEDAYAEFVERLDRSPALNP
RLKKTLQTPAPWDKR

Download         Length: 288 bp

>AT21156 NC_006513:3541039-3541326 [Aromatoleum aromaticum EbN1]
ATGTCTGCGGCCAATTCCATCGCCAAACGCGACACATTGAATCTGCGCATTAAGCCCGAAGTGCGCGGTTTGATTGACCG
CGCGGCCAAGGTGCGGGGCAAGAACCGCACCGACTTCATCCTGGACGCGGCACGCAATGCAGCCGAAGAGGCGTTGCTGG
ATCAGGCTTTGTTCCTGGTCAGTGAAGACGCCTATGCCGAGTTTGTCGAGCGTCTGGACCGATCCCCTGCACTCAATCCG
CGACTGAAAAAGACTTTGCAAACACCGGCGCCGTGGGACAAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References