Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1162985..1163628 Replicon chromosome
Accession NZ_CP080273
Organism Mycolicibacterium smegmatis strain Nishi

Toxin (Protein)


Gene name vapC Uniprot ID A0A2U9PKL6
Locus tag KZ781_RS05290 Protein ID WP_036452755.1
Coordinates 1163239..1163628 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag KZ781_RS05285 Protein ID WP_003892665.1
Coordinates 1162985..1163239 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ781_RS05275 (KZ781_05220) 1158415..1161798 + 3384 WP_239708045.1 ATP-binding protein -
KZ781_RS05280 (KZ781_05225) 1161795..1162964 + 1170 WP_233044284.1 DUF3322 and DUF2220 domain-containing protein -
KZ781_RS05285 (KZ781_05230) 1162985..1163239 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KZ781_RS05290 (KZ781_05235) 1163239..1163628 + 390 WP_036452755.1 type II toxin-antitoxin system VapC family toxin Toxin
KZ781_RS05295 (KZ781_05240) 1163647..1166067 - 2421 WP_239708046.1 SEC-C metal-binding domain-containing protein -
KZ781_RS05300 (KZ781_05245) 1166089..1167849 - 1761 WP_239708048.1 sulfatase-like hydrolase/transferase -
KZ781_RS05305 (KZ781_05250) 1167846..1168283 - 438 WP_239708050.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13953.74 Da        Isoelectric Point: 4.5959

>T211559 WP_036452755.1 NZ_CP080273:1163239-1163628 [Mycolicibacterium smegmatis]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEDFRLTDVAAVH

Download         Length: 390 bp

>T211559 NZ_CP104964:340351-340824 [Devosia neptuniae]
TTGCAGGCGCCTTCCCGACTTTCCGAGCAGCATAGGCTTGAGGACTTTTCCTCCGGCGAGGTTGTTCTCGACACTTGGCT
CAAAACCCGGGCTCTGCCCAACCAGGCGGCGGGTGTTTCTCGGACCTACGTCGCAGTTGAGGGTGGCCAGGTGGCAGGGT
ATTACTGCCTCAGCTCCGCGGCAATTAGCTTGAAAGAGGCACCTAGGGCACTGCGCCACGGTATGCCGGATCCTTTGCCG
ATGATCCTGATGGGCAGACTTGCGGTCGATCAGCGATATAAGGGGCAGGGGCTCGGAACTGCGCTCCTGAAAGACTCCGT
TCTGAGAGCACAATCAGCCCTGGAAATAATTGGGGTCCGCGGGCTCCTGGTTCATGCTCTTCATGACCAGGCTAAGGGCT
TCTATCTGCATCACGGTTTCCGTGAGACGCCCGGAAACCCGCTCACACTGGTTCTGCCCTTCAAGTTTACATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT211559 WP_003892665.1 NZ_CP080273:1162985-1163239 [Mycolicibacterium smegmatis]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp

>AT211559 NZ_CP104964:340060-340347 [Devosia neptuniae]
ATGCCGGCAAAAGAAGACCAAAAAATAAGCACTTCCGTCCCAATCAACTTGCGGATTCCGCGAGAGGCGCAGCTTATGAT
CGACCGGGCGGCCAAGCTATCCGGTAAGAACCGCACCGAATTCATGGTGGAGGCAGCCATGGCAGCAGCAGAAGACAAGC
TGCTGGACCAGGCTTTCATCGCACTCGACGCGCAAGCCTACGCTCAGTTCCTGGATGTTCTTGATAGGGGGCCAGAGCCC
GAAGGGTACAAGCGCTTGATGAGTGCGCCTTCGCCCTGGGGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U9PKL6

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References