Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1444689..1445332 Replicon chromosome
Accession NZ_CP080272
Organism Mycolicibacterium smegmatis strain Rabinowitchi

Toxin (Protein)


Gene name vapC Uniprot ID A0A2U9PKL6
Locus tag KZ782_RS06500 Protein ID WP_036452755.1
Coordinates 1444943..1445332 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag KZ782_RS06495 Protein ID WP_003892665.1
Coordinates 1444689..1444943 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ782_RS06485 (KZ782_06445) 1440119..1443502 + 3384 WP_233044282.1 ATP-binding protein -
KZ782_RS06490 (KZ782_06450) 1443499..1444668 + 1170 WP_233044284.1 DUF3322 and DUF2220 domain-containing protein -
KZ782_RS06495 (KZ782_06455) 1444689..1444943 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KZ782_RS06500 (KZ782_06460) 1444943..1445332 + 390 WP_036452755.1 type II toxin-antitoxin system VapC family toxin Toxin
KZ782_RS06505 (KZ782_06465) 1445351..1447770 - 2420 Protein_1295 SEC-C domain-containing protein -
KZ782_RS06510 (KZ782_06470) 1447792..1449552 - 1761 WP_239738842.1 sulfatase-like hydrolase/transferase -
KZ782_RS06515 (KZ782_06475) 1449549..1449986 - 438 WP_233044289.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13953.74 Da        Isoelectric Point: 4.5959

>T211554 WP_036452755.1 NZ_CP080272:1444943-1445332 [Mycolicibacterium smegmatis]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEDFRLTDVAAVH

Download         Length: 390 bp

>T211554 NZ_CP104925:c4799637-4799380 [Klebsiella pasteurii]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACGTTCGCGATACATC
AGGCCGCGTCACCTCCGTTGAATGCTACAGCCGCGAAGGGCTCTTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAACAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT211554 WP_003892665.1 NZ_CP080272:1444689-1444943 [Mycolicibacterium smegmatis]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp

>AT211554 NZ_CP104925:c4799369-4798818 [Klebsiella pasteurii]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCAATGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCTCTTTGCTCAACGATGAGAGCGCCTGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAAAGGCGGTTGGGCATATTTTATTCACCCGGGCGATGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGCGCTTATCCGGCACGGCATTGAGCA
GTTGAAAACCATGGGAAGCCAGACGGTATTTGTTCTGGGCCACGCCACTTACTACCCCAGGCACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGAGGCGCATAAAGCCTGCTGGATGCTACAGCGGCTTTCGTCT
CAGCCGCTGGGGCGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U9PKL6

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References