Detailed information of TA system TA211552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 787863..788560
• Replicon: chromosome
• Accession: NZ_CP080272
• Organism: Mycolicibacterium smegmatis strain Rabinowitchi

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KZ782_RS03435
• Protein ID: WP_081319354.1
• Coordinates: 787863..788294 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KZ782_RS03440
• Protein ID: WP_058125156.1
• Coordinates: 788303..788560 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ782_RS03415 (KZ782_03400)	783886..784794	+	909	WP_058125151.1	MBL fold metallo-hydrolase	-
KZ782_RS03420 (KZ782_03405)	784787..786178	+	1392	WP_233044019.1	carboxylesterase family protein	-
KZ782_RS03425 (KZ782_03410)	786235..786867	-	633	WP_058125153.1	TetR/AcrR family transcriptional regulator	-
KZ782_RS03430 (KZ782_03415)	786946..787851	+	906	WP_058125154.1	oxygenase MpaB family protein	-
KZ782_RS03435 (KZ782_03420)	787863..788294	-	432	WP_081319354.1	type II toxin-antitoxin system VapC family toxin	Toxin
KZ782_RS03440 (KZ782_03425)	788303..788560	-	258	WP_058125156.1	ribbon-helix-helix protein, CopG family	Antitoxin
KZ782_RS03445 (KZ782_03430)	788659..789561	+	903	WP_058127516.1	class I SAM-dependent methyltransferase	-
KZ782_RS03450 (KZ782_03435)	789748..791517	+	1770	WP_269821476.1	type VII secretion AAA-ATPase EccA	-
KZ782_RS03455 (KZ782_03440)	791514..793070	+	1557	WP_233044023.1	type VII secretion protein EccB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	738068..789561	51493

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-132)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-39)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15939.08 Da
• Isoelectric Point: 6.1461

>T211552 WP_081319354.1 NZ_CP080272:c788294-787863 [Mycolicibacterium smegmatis]
MFLLDVNVVLAAYRADHPDHATVRPWFDRLLDGDGPFTVPVQVWASFLRLVTNRRIFPVPTPRDDAFAFIEAVNGQPHHV
PVSAGPRHLALLHQLCDEGDASGDLIPDAVLAAIAHEHHCDVATLDRDFARFTTVRHLRPSLD

Nucleotide

• Length: 432 bp

>T211552 NZ_CP104925:4535867-4536085 [Klebsiella pasteurii]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCACCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9140.34 Da
• Isoelectric Point: 5.8508

>AT211552 WP_058125156.1 NZ_CP080272:c788560-788303 [Mycolicibacterium smegmatis]
VRTTIAIADELLAAAKRRARQRGQSLGSVIEDALRRELAADQEAAPRPEVPVFTDGTGPRAGIDLRSARALHEVLDEGLD
LNALK

Nucleotide

• Length: 258 bp

>AT211552 NZ_CP104925:4535466-4535840 [Klebsiella pasteurii]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCAACTTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGATTACTCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGTGCGGATCTGCAGAAATGGCGCAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG