Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 787863..788560 Replicon chromosome
Accession NZ_CP080272
Organism Mycolicibacterium smegmatis strain Rabinowitchi

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ782_RS03435 Protein ID WP_081319354.1
Coordinates 787863..788294 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ782_RS03440 Protein ID WP_058125156.1
Coordinates 788303..788560 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ782_RS03415 (KZ782_03400) 783886..784794 + 909 WP_058125151.1 MBL fold metallo-hydrolase -
KZ782_RS03420 (KZ782_03405) 784787..786178 + 1392 WP_233044019.1 carboxylesterase family protein -
KZ782_RS03425 (KZ782_03410) 786235..786867 - 633 WP_058125153.1 TetR/AcrR family transcriptional regulator -
KZ782_RS03430 (KZ782_03415) 786946..787851 + 906 WP_058125154.1 oxygenase MpaB family protein -
KZ782_RS03435 (KZ782_03420) 787863..788294 - 432 WP_081319354.1 type II toxin-antitoxin system VapC family toxin Toxin
KZ782_RS03440 (KZ782_03425) 788303..788560 - 258 WP_058125156.1 ribbon-helix-helix protein, CopG family Antitoxin
KZ782_RS03445 (KZ782_03430) 788659..789561 + 903 WP_058127516.1 class I SAM-dependent methyltransferase -
KZ782_RS03450 (KZ782_03435) 789748..791517 + 1770 WP_269821476.1 type VII secretion AAA-ATPase EccA -
KZ782_RS03455 (KZ782_03440) 791514..793070 + 1557 WP_233044023.1 type VII secretion protein EccB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 738068..789561 51493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15939.08 Da        Isoelectric Point: 6.1461

>T211552 WP_081319354.1 NZ_CP080272:c788294-787863 [Mycolicibacterium smegmatis]
MFLLDVNVVLAAYRADHPDHATVRPWFDRLLDGDGPFTVPVQVWASFLRLVTNRRIFPVPTPRDDAFAFIEAVNGQPHHV
PVSAGPRHLALLHQLCDEGDASGDLIPDAVLAAIAHEHHCDVATLDRDFARFTTVRHLRPSLD

Download         Length: 432 bp

>T211552 NZ_CP104925:4535867-4536085 [Klebsiella pasteurii]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCACCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9140.34 Da        Isoelectric Point: 5.8508

>AT211552 WP_058125156.1 NZ_CP080272:c788560-788303 [Mycolicibacterium smegmatis]
VRTTIAIADELLAAAKRRARQRGQSLGSVIEDALRRELAADQEAAPRPEVPVFTDGTGPRAGIDLRSARALHEVLDEGLD
LNALK

Download         Length: 258 bp

>AT211552 NZ_CP104925:4535466-4535840 [Klebsiella pasteurii]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCAACTTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGATTACTCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGTGCGGATCTGCAGAAATGGCGCAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References