Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3483752..3484354 Replicon chromosome
Accession NC_006513
Organism Aromatoleum aromaticum EbN1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EB_RS16305 Protein ID WP_011239114.1
Coordinates 3483752..3484042 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag EB_RS16310 Protein ID WP_041646526.1
Coordinates 3484052..3484354 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EB_RS16270 3479032..3479301 + 270 WP_011239109.1 30S ribosomal protein S15 -
EB_RS16275 3479464..3481563 + 2100 WP_011239110.1 polyribonucleotide nucleotidyltransferase -
EB_RS16280 3481649..3482074 - 426 WP_011239111.1 RNA polymerase-binding protein DksA -
EB_RS16300 3482620..3483474 - 855 WP_157866635.1 hypothetical protein -
EB_RS16305 3483752..3484042 + 291 WP_011239114.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EB_RS16310 3484052..3484354 + 303 WP_041646526.1 putative addiction module antidote protein Antitoxin
EB_RS24340 3484955..3485113 + 159 WP_157866636.1 hypothetical protein -
EB_RS16315 3485155..3486555 + 1401 WP_011239116.1 putative DNA binding domain-containing protein -
EB_RS16320 3486558..3488012 + 1455 WP_011239117.1 MBL fold metallo-hydrolase -
EB_RS16325 3488260..3488790 + 531 WP_197531910.1 nucleotidyltransferase domain-containing protein -
EB_RS16330 3488780..3489217 + 438 WP_011239119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10721.38 Da        Isoelectric Point: 7.9987

>T21154 WP_011239114.1 NC_006513:3483752-3484042 [Aromatoleum aromaticum EbN1]
MKTVLTTEFFDAWFAELRDPQAAARIKMRIGRAELGNFGDCEPVGEGVSEMRIHYGPGYRLYFTQRGLEVVILLAGGDKS
SQAKDIKTALKLAREL

Download         Length: 291 bp

>T21154 NC_006513:3483752-3484042 [Aromatoleum aromaticum EbN1]
ATGAAGACTGTGCTCACCACCGAATTCTTCGATGCCTGGTTTGCCGAGCTCCGCGACCCGCAGGCGGCAGCCCGCATCAA
GATGCGAATCGGTCGGGCAGAGTTGGGCAACTTCGGCGACTGCGAACCGGTGGGCGAGGGGGTTTCGGAGATGCGGATCC
ATTACGGGCCGGGCTACCGCCTGTATTTCACGCAGCGCGGCCTGGAAGTGGTGATCCTGCTGGCGGGCGGCGACAAGTCC
TCCCAGGCCAAGGACATCAAGACCGCCTTGAAGCTGGCCCGGGAACTGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10777.43 Da        Isoelectric Point: 6.7188

>AT21154 WP_041646526.1 NC_006513:3484052-3484354 [Aromatoleum aromaticum EbN1]
MALKLRKWDTAEHLKTEEEMALYLEACLEEAGDDAAFIAKALGDIARAKGMTQLAKDTGLGRESLYKALSGEGNPSFATI
LKVTRALGLQLHAAPRHAPV

Download         Length: 303 bp

>AT21154 NC_006513:3484052-3484354 [Aromatoleum aromaticum EbN1]
ATGGCACTCAAATTGCGCAAATGGGACACGGCAGAGCACCTCAAGACCGAGGAGGAGATGGCGCTCTACCTCGAGGCTTG
TCTGGAAGAAGCCGGGGACGATGCAGCCTTTATCGCGAAGGCACTGGGCGATATTGCCCGCGCCAAAGGCATGACCCAAC
TGGCCAAGGACACCGGTCTGGGGCGGGAGAGCCTGTACAAGGCCCTTTCGGGCGAGGGCAATCCGAGCTTTGCCACCATC
CTCAAGGTGACACGCGCGTTGGGCCTGCAACTGCACGCGGCACCGCGCCACGCGCCGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References