Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3325757..3326626 Replicon chromosome
Accession NZ_CP080260
Organism Escherichia coli strain 135

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0U4BLW2
Locus tag KZ312_RS16015 Protein ID WP_059309235.1
Coordinates 3326216..3326626 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0X5FMN2
Locus tag KZ312_RS16010 Protein ID WP_039023579.1
Coordinates 3325757..3326125 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ312_RS15970 (3320968) 3320968..3321851 + 884 Protein_3126 50S ribosome-binding GTPase -
KZ312_RS15975 (3321970) 3321970..3322647 + 678 WP_219790042.1 hypothetical protein -
KZ312_RS15980 (3322653) 3322653..3322802 + 150 WP_219790044.1 DUF905 family protein -
KZ312_RS15985 (3322903) 3322903..3323724 + 822 WP_219790046.1 DUF932 domain-containing protein -
KZ312_RS15990 (3323806) 3323806..3324285 + 480 WP_203397206.1 antirestriction protein -
KZ312_RS15995 (3324301) 3324301..3324777 + 477 WP_001349449.1 RadC family protein -
KZ312_RS16000 (3324840) 3324840..3325061 + 222 WP_000692315.1 DUF987 domain-containing protein -
KZ312_RS29105 (3325076) 3325076..3325707 + 632 Protein_3133 antitoxin of toxin-antitoxin stability system -
KZ312_RS16010 (3325757) 3325757..3326125 + 369 WP_039023579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZ312_RS16015 (3326216) 3326216..3326626 + 411 WP_059309235.1 TA system toxin CbtA family protein Toxin
KZ312_RS16020 (3326589) 3326589..3326738 + 150 Protein_3136 DUF5983 family protein -
KZ312_RS16025 (3326814) 3326814..3327011 + 198 WP_085975623.1 DUF957 domain-containing protein -
KZ312_RS16030 (3327096) 3327096..3327892 + 797 Protein_3138 DUF4942 domain-containing protein -
KZ312_RS16035 (3328112) 3328112..3329278 + 1167 WP_001587129.1 ABC transporter substrate-binding protein -
KZ312_RS16040 (3329251) 3329251..3330786 + 1536 WP_000224996.1 ABC transporter permease subunit -
KZ312_RS16045 (3330786) 3330786..3331439 + 654 WP_001587131.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3319912..3339449 19537


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15234.33 Da        Isoelectric Point: 6.8522

>T211531 WP_059309235.1 NZ_CP080260:3326216-3326626 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITLGSIRGRNDETFPDAGSRQH

Download         Length: 411 bp

>T211531 NZ_CP104917:113760-114050 [Avibacterium paragallinarum]
ATGACCTATAAACTTTCTTTTGATAAACGGGCATTAAAAGAATGGCATAAATTGGGCGATACCCTACGTCAGCAATTTAA
AGCAAAATTAATCGAACGGCTGGAAAATCCCCACGTTTTAAGCGATAAATTGCACGGTTATCAAACGCTTTATAAAATTA
AATTGCGATCAGCGGGCTATCGGCTTGTTTATGATGTCAATGACAATGAAATTAGAGTTATTGTGCTTTCAGTAGGCAAA
AGAGAACGCCTACAAGCCTATAAAAAAGCCCTATCAAGAAAAGCCCAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13672.49 Da        Isoelectric Point: 6.7393

>AT211531 WP_039023579.1 NZ_CP080260:3325757-3326125 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT211531 NZ_CP104917:113510-113770 [Avibacterium paragallinarum]
ATGGCAATTCAGCAAATTTTAACCCGCCACACGGCAAGCATTAGCGACTTGAAAAAAAATCCTATGGGGATTGTATCAGA
GGGAACAGAGCAAGAAGGGGCGATCGCTATTCTAAACCGTAATGAACCCGTGTTTTATTGCGTAAATCCCCGTCTTTTTG
CGGTTATTCAAGAAATCCTTGAAGACAAAGAACTAGGCGAACTCGCCACACAACGCCTTGCAACCCTTGACCCCGTCGAG
GTGCGTTTAGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4BLW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0X5FMN2

References