Detailed information of TA system TA211530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3025790..3027378
• Replicon: chromosome
• Accession: NZ_CP080260
• Organism: Escherichia coli strain 135

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A244BTZ1
• Locus tag: KZ312_RS14525
• Protein ID: WP_001125443.1
• Coordinates: 3025790..3027112 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KZ312_RS14530
• Protein ID: WP_042027983.1
• Coordinates: 3027112..3027378 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ312_RS14490 (3020836)	3020836..3021408	-	573	WP_000789914.1	NAD(P)H-dependent oxidoreductase	-
KZ312_RS14495 (3021558)	3021558..3021710	-	153	WP_001314732.1	amidohydrolase family protein	-
KZ312_RS14500 (3021700)	3021700..3022119	-	420	WP_001314733.1	amidohydrolase family protein	-
KZ312_RS14505 (3022337)	3022337..3023284	-	948	WP_000854796.1	aldo/keto reductase	-
KZ312_RS14510 (3023346)	3023346..3024035	-	690	WP_000801314.1	type 1 glutamine amidotransferase domain-containing protein	-
KZ312_RS14515 (3024044)	3024044..3024352	-	309	WP_001221046.1	hypothetical protein	-
KZ312_RS14520 (3024492)	3024492..3025391	+	900	WP_001057776.1	LysR family transcriptional regulator	-
KZ312_RS14525 (3025790)	3025790..3027112	-	1323	WP_001125443.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
KZ312_RS14530 (3027112)	3027112..3027378	-	267	WP_042027983.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49275.90 Da
• Isoelectric Point: 8.2472

>T211530 WP_001125443.1 NZ_CP080260:c3027112-3025790 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLTSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKLLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Nucleotide

• Length: 1323 bp

>T211530 NZ_CP104914:2186761-2186943 [Avibacterium paragallinarum]
ATGAAATACAGTGAATTCTTGCGATACTTGCTTGAGCAAGGCTGTAAAGTCGAAAATACAAAGCGAGGAAGCCATCGCAA
GGTAACGTTGAACGGACACCAAACTGTATTTCCCTACCACGGTAGTCAAGAAATCGGAACAGGGTTAGTTCACAAAATCA
AAAAAGACTTAAATTTAAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10044.39 Da
• Isoelectric Point: 4.9632

>AT211530 WP_042027983.1 NZ_CP080260:c3027378-3027112 [Escherichia coli]
MMSFQKIYNPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT211530 NZ_CP104914:2186996-2187415 [Avibacterium paragallinarum]
ATGTTACGTTATCCTGTTGAATTAAAAGCCGATGATAACGGCACGTTTCTTGTTACCTTTCCTGATATTCCCGAAGCGGC
AAGTGTAGGAGAAGACCTTGAAAGTGCCTTACTTGAAGCAGAGGAAGGATTAGAAACCGCACTGGAATTTTATTTTGATG
ATAAACGCCCAATCCCATTACCGAGTAAACCTCAAGAGGGGCAATATACTGTTCCGCTCTCTTTATTGCGCTCATTAAAA
GTGTTATTACTGAATGAAATGCTCGCTCAAGGTGTTCGCAAAGCAGAAATGGCTCGTCGCCTTGATGTACATATGCCACA
AATCGATCGCTTATTAGATTTTCGCTATCCTTCTAAAATTGATTTTGTTGAAAAAGCCTTTAAAAAACTAGGGCGGGAAA
TTCATTTGGCGGTGAGTTAA

Structures

Toxin

• AlphaFold DB: A0A244BTZ1