Detailed information of TA system TA021152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 2046775..2047346
• Replicon: chromosome
• Accession: NC_006513
• Organism: Aromatoleum aromaticum EbN1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5P3P1
• Locus tag: EB_RS09545
• Protein ID: WP_011237766.1
• Coordinates: 2047053..2047346 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: EB_RS09540
• Protein ID: WP_041646138.1
• Coordinates: 2046775..2047065 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB_RS09520	2041817..2042308	+	492	WP_011237761.1	MarR family transcriptional regulator	-
EB_RS09525	2042333..2043760	+	1428	WP_011237762.1	efflux transporter outer membrane subunit	-
EB_RS09530	2043783..2045084	+	1302	WP_011237763.1	HlyD family efflux transporter periplasmic adaptor subunit	-
EB_RS09535	2045102..2046646	+	1545	WP_011237764.1	DHA2 family efflux MFS transporter permease subunit	-
EB_RS09540	2046775..2047065	+	291	WP_041646138.1	CopG family ribbon-helix-helix protein	Antitoxin
EB_RS09545	2047053..2047346	+	294	WP_011237766.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EB_RS09550	2047957..2049176	-	1220	Protein_1899	IS110 family transposase	-
EB_RS22955	2049597..2049944	-	348	WP_083782958.1	PIN domain-containing protein	-
EB_RS09560	2049931..2050206	-	276	WP_041646140.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EB_RS09565	2050367..2050762	-	396	WP_011237771.1	type II toxin-antitoxin system VapC family toxin	-
EB_RS09570	2050759..2051001	-	243	WP_041646142.1	Arc family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2047989..2049176	1187

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10962.55 Da
• Isoelectric Point: 8.5368

>T21152 WP_011237766.1 NC_006513:2047053-2047346 [Aromatoleum aromaticum EbN1]
MPQVRFAPAALRDLERLRDFLRPKNPAAAKRAAAAIIKAVQVLGQQPHIGRPVADLPEEFREWPIEFGDSGYVARYRYDA
NEDVIILGIRHQKEAGE

Nucleotide

• Length: 294 bp

>T21152 NC_006513:2047053-2047346 [Aromatoleum aromaticum EbN1]
ATGCCGCAAGTGAGATTCGCGCCTGCGGCGCTGCGCGACCTGGAGCGGCTGCGCGACTTCCTGCGTCCGAAGAATCCCGC
GGCCGCAAAGCGGGCTGCTGCGGCAATCATCAAGGCAGTTCAGGTTCTCGGACAACAACCGCACATCGGCCGCCCGGTGG
CCGATCTGCCCGAGGAATTCCGGGAGTGGCCGATCGAATTCGGCGACAGCGGGTATGTGGCGAGGTATCGCTACGACGCG
AACGAAGACGTGATCATCTTGGGGATTCGTCACCAGAAAGAGGCGGGTGAGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11219.53 Da
• Isoelectric Point: 5.6919

>AT21152 WP_041646138.1 NC_006513:2046775-2047065 [Aromatoleum aromaticum EbN1]
MPTTAAKTVSVKLDDEMRDRIKHLAETRHRTTHWVMREAIQQYVEREEKREAFRQATLAAWEEYQETGVSVAADEVTAWL
ETWGESNEQAAPKCRK

Nucleotide

• Length: 291 bp

>AT21152 NC_006513:2046775-2047065 [Aromatoleum aromaticum EbN1]
ATGCCGACCACCGCTGCCAAGACGGTATCCGTAAAGCTCGACGACGAGATGCGGGACCGCATCAAGCATCTTGCCGAGAC
TCGTCATCGCACCACGCATTGGGTGATGCGGGAGGCGATCCAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCATTCC
GGCAGGCGACCCTGGCAGCCTGGGAGGAATATCAGGAAACAGGCGTATCCGTAGCCGCGGACGAGGTCACCGCTTGGCTC
GAAACCTGGGGTGAAAGCAACGAGCAAGCCGCGCCCAAATGCCGCAAGTGA

Structures

Toxin

• AlphaFold DB: Q5P3P1