Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2378714..2379515 Replicon chromosome
Accession NZ_CP080260
Organism Escherichia coli strain 135

Toxin (Protein)


Gene name yeeV Uniprot ID D8EF64
Locus tag KZ312_RS11155 Protein ID WP_000847116.1
Coordinates 2379138..2379515 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0D8WE31
Locus tag KZ312_RS11150 Protein ID WP_032289760.1
Coordinates 2378714..2379079 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ312_RS11110 (2374849) 2374849..2375040 + 192 Protein_2162 hypothetical protein -
KZ312_RS11115 (2375037) 2375037..2375402 + 366 Protein_2163 hypothetical protein -
KZ312_RS11120 (2375602) 2375602..2375706 + 105 WP_106421522.1 DUF905 family protein -
KZ312_RS11125 (2375807) 2375807..2376625 + 819 WP_045147259.1 DUF932 domain-containing protein -
KZ312_RS11130 (2376730) 2376730..2377203 + 474 WP_000860015.1 antirestriction protein -
KZ312_RS11135 (2377215) 2377215..2377691 + 477 WP_001186164.1 RadC family protein -
KZ312_RS11140 (2377781) 2377781..2378002 + 222 WP_000692361.1 DUF987 domain-containing protein -
KZ312_RS11145 (2378019) 2378019..2378663 + 645 WP_045145966.1 hypothetical protein -
KZ312_RS11150 (2378714) 2378714..2379079 + 366 WP_032289760.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZ312_RS11155 (2379138) 2379138..2379515 + 378 WP_000847116.1 TA system toxin CbtA family protein Toxin
KZ312_RS11160 (2379512) 2379512..2380000 + 489 WP_000777671.1 DUF5983 family protein -
KZ312_RS11165 (2380020) 2380020..2380217 + 198 WP_001349630.1 DUF957 domain-containing protein -
KZ312_RS11170 (2380314) 2380314..2381156 + 843 WP_029490447.1 DUF4942 domain-containing protein -
KZ312_RS11180 (2381629) 2381629..2382567 + 939 WP_000351282.1 glyoxylate/hydroxypyruvate reductase GhrA -
KZ312_RS11185 (2382622) 2382622..2383359 + 738 WP_000283664.1 zinc-binding phosphatase -
KZ312_RS11190 (2383383) 2383383..2383937 + 555 WP_001001909.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 2356415..2390098 33683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14053.10 Da        Isoelectric Point: 7.8276

>T211518 WP_000847116.1 NZ_CP080260:2379138-2379515 [Escherichia coli]
MKTFPDTHVRATSRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLISSIDILRARRATGLMTRSHYRMVNNITLGKHCEVKP

Download         Length: 378 bp

>T211518 NZ_CP104912:255668-256057 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13357.08 Da        Isoelectric Point: 5.9483

>AT211518 WP_032289760.1 NZ_CP080260:2378714-2379079 [Escherichia coli]
MSDTLTGTTHPDDNSDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCDADTLGSCGYVYIAIYPTPATP

Download         Length: 366 bp

>AT211518 NZ_CP104912:255404-255661 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2EUN0

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WE31

References