Detailed information of TA system TA211517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 2079030..2079735
• Replicon: chromosome
• Accession: NZ_CP080260
• Organism: Escherichia coli strain 135

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: KZ312_RS09705
• Protein ID: WP_000539521.1
• Coordinates: 2079349..2079735 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KZ312_RS09700
• Protein ID: WP_001280945.1
• Coordinates: 2079030..2079359 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ312_RS09685 (2074195)	2074195..2075106	+	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-
KZ312_RS09690 (2075284)	2075284..2077624	+	2341	Protein_1879	EAL domain-containing protein	-
KZ312_RS09695 (2077632)	2077632..2078960	+	1329	WP_021564116.1	GGDEF domain-containing protein	-
KZ312_RS09700 (2079030)	2079030..2079359	-	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
KZ312_RS09705 (2079349)	2079349..2079735	-	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ312_RS09710 (2079961)	2079961..2081286	-	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
KZ312_RS09715 (2081499)	2081499..2081882	+	384	WP_000497137.1	biofilm formation regulator BssR	-
KZ312_RS09720 (2081993)	2081993..2083108	+	1116	WP_000555033.1	aldose sugar dehydrogenase YliI	-
KZ312_RS09725 (2083105)	2083105..2083731	-	627	WP_001314584.1	glutathione S-transferase GstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T211517 WP_000539521.1 NZ_CP080260:c2079735-2079349 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T211517 NZ_CP104911:c5918-5631 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT211517 WP_001280945.1 NZ_CP080260:c2079359-2079030 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT211517 NZ_CP104911:c5644-5330 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6