211516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1604267..1604885 Replicon chromosome
Accession NZ_CP080260
Organism Escherichia coli strain 135

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KZ312_RS07395 Protein ID WP_001291435.1
Coordinates 1604267..1604485 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KZ312_RS07400 Protein ID WP_000344800.1
Coordinates 1604511..1604885 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ312_RS07360 (1599556) 1599556..1600128 + 573 WP_000779826.1 YbaY family lipoprotein -
KZ312_RS07365 (1600159) 1600159..1600470 - 312 WP_000409911.1 MGMT family protein -
KZ312_RS07375 (1600849) 1600849..1601202 + 354 WP_000878140.1 DUF1428 domain-containing protein -
KZ312_RS07380 (1601244) 1601244..1602794 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KZ312_RS07385 (1602958) 1602958..1603428 - 471 WP_000136192.1 YlaC family protein -
KZ312_RS07390 (1603544) 1603544..1604095 - 552 WP_000102564.1 maltose O-acetyltransferase -
KZ312_RS07395 (1604267) 1604267..1604485 - 219 WP_001291435.1 HHA domain-containing protein Toxin
KZ312_RS07400 (1604511) 1604511..1604885 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KZ312_RS07405 (1605431) 1605431..1608580 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
KZ312_RS07410 (1608603) 1608603..1609796 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T211516 WP_001291435.1 NZ_CP080260:c1604485-1604267 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T211516 NZ_CP104910:1000-1287 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT211516 WP_000344800.1 NZ_CP080260:c1604885-1604511 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT211516 NZ_CP104910:1274-1588 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References