Detailed information of TA system TA211515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1401440..1403093
• Replicon: chromosome
• Accession: NZ_CP080260
• Organism: Escherichia coli strain 135

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A0X5EJM1
• Locus tag: KZ312_RS06480
• Protein ID: WP_001615045.1
• Coordinates: 1402209..1403093 (+)
• Length: 295 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KZ312_RS06475
• Protein ID: WP_001134467.1
• Coordinates: 1401440..1402222 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ312_RS06450 (1396893)	1396893..1398218	-	1326	WP_001586702.1	DNA phosphorothioation-dependent restriction protein DptG	-
KZ312_RS06455 (1398223)	1398223..1399872	-	1650	WP_001586703.1	DNA phosphorothioation-dependent restriction protein DptF	-
KZ312_RS06460 (1400149)	1400149..1400373	-	225	WP_024187424.1	helix-turn-helix transcriptional regulator	-
KZ312_RS06465 (1400454)	1400454..1400684	-	231	WP_001577779.1	helix-turn-helix transcriptional regulator	-
KZ312_RS06470 (1400753)	1400753..1401063	+	311	Protein_1250	helix-turn-helix domain-containing protein	-
KZ312_RS06475 (1401440)	1401440..1402222	+	783	WP_001134467.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
KZ312_RS06480 (1402209)	1402209..1403093	+	885	WP_001615045.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KZ312_RS06485 (1403545)	1403545..1404429	-	885	WP_001119037.1	LysR family transcriptional regulator	-
KZ312_RS06490 (1404694)	1404694..1405752	+	1059	WP_001586705.1	alpha/beta hydrolase	-
KZ312_RS06495 (1405894)	1405894..1407021	+	1128	WP_000171079.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-209)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 295 a.a.
• Molecular weight: 33151.42 Da
• Isoelectric Point: 7.7408

>T211515 WP_001615045.1 NZ_CP080260:1402209-1403093 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAAINDALKRITASLNGRPGITAIRQENKA
DEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQHPRDLFDVLNMLE
KPGVMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQALKSHLTDLDREFS
LSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 885 bp

>T211515 NZ_CP104909:c55333-54974 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29093.39 Da
• Isoelectric Point: 8.4395

>AT211515 WP_001134467.1 NZ_CP080260:1401440-1402222 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSLTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQALLCASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT211515 NZ_CP104909:c54974-54675 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA

Structures

Toxin

• AlphaFold DB: A0A0X5EJM1