211511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 917511..918033 Replicon chromosome
Accession NZ_CP080260
Organism Escherichia coli strain 135

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag KZ312_RS04280 Protein ID WP_001105433.1
Coordinates 917743..918033 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag KZ312_RS04275 Protein ID WP_000212715.1
Coordinates 917511..917753 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ312_RS04255 (913425) 913425..914798 + 1374 WP_059327939.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
KZ312_RS04260 (914881) 914881..915432 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
KZ312_RS04265 (915526) 915526..916878 + 1353 WP_001162171.1 metalloprotease PmbA -
KZ312_RS04270 (916933) 916933..917319 + 387 WP_001232253.1 cytochrome b562 -
KZ312_RS04275 (917511) 917511..917753 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KZ312_RS04280 (917743) 917743..918033 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ312_RS04285 (918034) 918034..918498 - 465 WP_086795215.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KZ312_RS04290 (918683) 918683..920821 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
KZ312_RS04295 (921215) 921215..922870 - 1656 WP_059327940.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T211511 WP_001105433.1 NZ_CP080260:917743-918033 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T211511 NZ_CP104900:c3077990-3077703 [Shewanella seohaensis]
ATGAAAGTAGTTTGGTCTCCATTAGCGCTTCAGAAGCTAGGCGATGCAGCGGAGTTTATTTCTTTGGATAATCCATCTGC
GGCAGAAAAGTGGGTAAATGAAGTTTTTGATAAAACCGAACTACTTGGAAGCATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATGCCCCATACGAACTATCGTGAAATCATCTTTGGTCACTATCGGATTATCTACAGCTTAAGTCACGAAATCCGCGTG
CTAACAGTTCGTAATTGTCGCCAAATACTGTCTGAAGATGACGTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT211511 WP_000212715.1 NZ_CP080260:917511-917753 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT211511 NZ_CP104900:c3078268-3077987 [Shewanella seohaensis]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCGTTATCTGAATTTCGTGCAGGTGTTGCTTCTTACATCAAACAAAT
CAATGAGACTCGCCGTCCATTGGTCATTACACAGCGTGGTAAAGGTGTTGCTGTTGTTCTTGATGTTGCAGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTAGAAGAAATGCGCACAGCTGAAGCTCAATTAGCTTCAGGCCTTGGTGTTTCCAAT
GATGATGCTCGTGCTCAAGTACTGGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References