Detailed information of TA system TA211510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 906088..906683
• Replicon: chromosome
• Accession: NZ_CP080260
• Organism: Escherichia coli strain 135

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: KZ312_RS04220
• Protein ID: WP_000239581.1
• Coordinates: 906333..906683 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: KZ312_RS04215
• Protein ID: WP_001223213.1
• Coordinates: 906088..906339 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ312_RS04205 (901753)	901753..905532	+	3780	WP_059327937.1	autotransporter assembly complex protein TamB	-
KZ312_RS04210 (905535)	905535..905876	+	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
KZ312_RS04215 (906088)	906088..906339	+	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
KZ312_RS04220 (906333)	906333..906683	+	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
KZ312_RS04225 (906762)	906762..907292	-	531	WP_000055075.1	inorganic diphosphatase	-
KZ312_RS04230 (907602)	907602..908558	+	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
KZ312_RS04235 (908698)	908698..910200	+	1503	WP_059327938.1	sugar ABC transporter ATP-binding protein	-
KZ312_RS04240 (910214)	910214..911236	+	1023	WP_001305656.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T211510 WP_000239581.1 NZ_CP080260:906333-906683 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T211510 NZ_CP104896:2568-2834 [Bartonella sp. HY406]
ATGAAATTGACATTTTCAACTGAGGCTTGGGAAGATTATCAATATTGGATAAGCACAGACAAAAAGAAGCTTGAACGTAT
TAATGAAATTATTACGCAATGCCAAAGAACACCCTATAAAGGCATAGGTAAACCAGAACCTTTAAAAGGCGATCTAAGCG
GATGGTGGTCAAGACGTATCACACAAGAACATCGAATAGTCTATCGTATTTCAAAGGAGAAACAAGCGCAAAGCTTAGAA
ATAGCACAATTGCGTTTTCATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT211510 WP_001223213.1 NZ_CP080260:906088-906339 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT211510 NZ_CP104896:2320-2568 [Bartonella sp. HY406]
ATGAATGTAATTTCTTATTCCAATGCTCGAGCGCAATTAAAAGACGTTATGGACAGCGCAATCCATGATAAACAAGAAGT
TGTCGTATCGCGAAAAAACGGTGAAGCCGTCGTTGTTATATCATTAGAGACATGGAACTCTATTAGCGAAACATTGCATC
TTCTTTCTACGCCTAATAACGCTTCGCGCTTGCGATCGGCTATTGCACAATTAGATGCCAATAATGGTGAAGAACACGAG
CTTATTTAA

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7