Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 755859..756698 Replicon chromosome
Accession NZ_CP080260
Organism Escherichia coli strain 135

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KZ312_RS03445 Protein ID WP_219790130.1
Coordinates 755859..756239 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KZ312_RS03450 Protein ID WP_134233648.1
Coordinates 756330..756698 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ312_RS03425 (752227) 752227..753765 - 1539 WP_001187199.1 lysine decarboxylation/transport transcriptional activator CadC -
KZ312_RS03430 (754514) 754514..755355 - 842 Protein_654 DUF4942 domain-containing protein -
KZ312_RS03435 (755440) 755440..755637 - 198 WP_085975623.1 DUF957 domain-containing protein -
KZ312_RS03440 (755680) 755680..755862 - 183 Protein_656 DUF5983 family protein -
KZ312_RS03445 (755859) 755859..756239 - 381 WP_219790130.1 TA system toxin CbtA family protein Toxin
KZ312_RS03450 (756330) 756330..756698 - 369 WP_134233648.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZ312_RS28905 (756748) 756748..757380 - 633 Protein_659 antitoxin of toxin-antitoxin stability system -
KZ312_RS03460 (757395) 757395..757616 - 222 WP_000692315.1 DUF987 domain-containing protein -
KZ312_RS03465 (757679) 757679..758155 - 477 WP_001366830.1 RadC family protein -
KZ312_RS03470 (758171) 758171..758649 - 479 Protein_662 antirestriction protein -
KZ312_RS03475 (758731) 758731..759549 - 819 WP_001234688.1 DUF932 domain-containing protein -
KZ312_RS03480 (759650) 759650..759802 - 153 WP_001696589.1 DUF905 family protein -
KZ312_RS03485 (759808) 759808..760485 - 678 WP_001097365.1 hypothetical protein -
KZ312_RS03490 (760604) 760604..761487 - 884 Protein_666 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14153.27 Da        Isoelectric Point: 6.8519

>T211509 WP_219790130.1 NZ_CP080260:c756239-755859 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNIPLGKHPEEAKQ

Download         Length: 381 bp

>T211509 NZ_CP104896:2320-2568 [Bartonella sp. HY406]
ATGAATGTAATTTCTTATTCCAATGCTCGAGCGCAATTAAAAGACGTTATGGACAGCGCAATCCATGATAAACAAGAAGT
TGTCGTATCGCGAAAAAACGGTGAAGCCGTCGTTGTTATATCATTAGAGACATGGAACTCTATTAGCGAAACATTGCATC
TTCTTTCTACGCCTAATAACGCTTCGCGCTTGCGATCGGCTATTGCACAATTAGATGCCAATAATGGTGAAGAACACGAG
CTTATTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13700.54 Da        Isoelectric Point: 6.7393

>AT211509 WP_134233648.1 NZ_CP080260:c756698-756330 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEVDTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT211509 NZ_CP104896:2568-2834 [Bartonella sp. HY406]
ATGAAATTGACATTTTCAACTGAGGCTTGGGAAGATTATCAATATTGGATAAGCACAGACAAAAAGAAGCTTGAACGTAT
TAATGAAATTATTACGCAATGCCAAAGAACACCCTATAAAGGCATAGGTAAACCAGAACCTTTAAAAGGCGATCTAAGCG
GATGGTGGTCAAGACGTATCACACAAGAACATCGAATAGTCTATCGTATTTCAAAGGAGAAACAAGCGCAAAGCTTAGAA
ATAGCACAATTGCGTTTTCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References