Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 185580..186415 Replicon chromosome
Accession NZ_CP080260
Organism Escherichia coli strain 135

Toxin (Protein)


Gene name yeeV Uniprot ID F4TIK8
Locus tag KZ312_RS00900 Protein ID WP_000854694.1
Coordinates 186038..186415 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4TIK7
Locus tag KZ312_RS00895 Protein ID WP_001285605.1
Coordinates 185580..185948 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ312_RS00845 (180870) 180870..181160 + 291 Protein_164 hypothetical protein -
KZ312_RS00850 (181234) 181234..182411 + 1178 WP_219790120.1 IS3 family transposase -
KZ312_RS00855 (182419) 182419..182808 + 390 Protein_166 hypothetical protein -
KZ312_RS00860 (182814) 182814..183047 + 234 WP_001278287.1 DUF905 family protein -
KZ312_RS00865 (183137) 183137..183955 + 819 WP_001175153.1 DUF932 domain-containing protein -
KZ312_RS00870 (183981) 183981..184121 - 141 WP_000997937.1 hypothetical protein -
KZ312_RS00875 (184221) 184221..184700 + 480 WP_001696591.1 antirestriction protein -
KZ312_RS00880 (184716) 184716..185192 + 477 WP_001696592.1 RadC family protein -
KZ312_RS28885 (185279) 185279..185500 + 222 Protein_172 DUF987 domain-containing protein -
KZ312_RS00895 (185580) 185580..185948 + 369 WP_001285605.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZ312_RS00900 (186038) 186038..186415 + 378 WP_000854694.1 TA system toxin CbtA family protein Toxin
KZ312_RS00905 (186412) 186412..186579 + 168 Protein_175 DUF5983 family protein -
KZ312_RS00910 (186637) 186637..186834 + 198 WP_086795284.1 DUF957 domain-containing protein -
KZ312_RS00915 (186919) 186919..187761 + 843 WP_001696593.1 DUF4942 domain-containing protein -
KZ312_RS00920 (187998) 187998..188126 + 129 Protein_178 virulence RhuM family protein -
KZ312_RS00925 (188556) 188556..189740 + 1185 WP_001172868.1 sugar efflux transporter -
KZ312_RS00930 (189851) 189851..190774 + 924 WP_000535948.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 138870..199383 60513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14008.02 Da        Isoelectric Point: 7.7293

>T211507 WP_000854694.1 NZ_CP080260:186038-186415 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T211507 NZ_CP104890:2569-2835 [Bartonella sp. HY761]
ATGAAATTGACATTTTCAACTGAGGCTTGGGAAGATTATCAATATTGGATAAGCACAGACAAAAAGAAGCTTGAACGTAT
TAATGAAATTATTACGCAATGCCAAAGAACACCCTATAAAGGCATAGGTAAACCAGAACCTTTAAAAGGCGATCTAAGCG
GATGGTGGTCAAGACGTATCACACAAGAACATCGAATAGTCTATCGCATTTCAGGGGAGAAACAAGCGCAAAGCTTAGAA
ATAGCACAATTGCGTTTTCATTATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.48 Da        Isoelectric Point: 6.0601

>AT211507 WP_001285605.1 NZ_CP080260:185580-185948 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRACIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT211507 NZ_CP104890:2321-2569 [Bartonella sp. HY761]
ATGAATGTAATTTCTTATTCCAATGCTCGAGCGCAATTAAAAGACGTTATGGACAGCGCAATCCATGATAAACAAGAAGT
TGTCGTATCGCGAAAAAACGGTGAAGCTGTCGTTGTTATATCATTAGAGACATGGAACTCTATTAGCGAAACATTGCATC
TTCTTTCTACGCCTAATAACGCTTCGCGCTTGCGATCGGCTATTGCACAATTAGATGCCAATAATGGTGAAGAACACGAG
CTTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2F934

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2V3N6

References