Detailed information of TA system TA211492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3158164..3158869
• Replicon: chromosome
• Accession: NZ_CP080255
• Organism: Escherichia coli strain SJC33

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: KZ313_RS15210
• Protein ID: WP_000539521.1
• Coordinates: 3158164..3158550 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KZ313_RS15215
• Protein ID: WP_001280945.1
• Coordinates: 3158540..3158869 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ313_RS15190 (3154168)	3154168..3154794	+	627	WP_001295292.1	glutathione S-transferase GstB	-
KZ313_RS15195 (3154791)	3154791..3155906	-	1116	WP_000555051.1	aldose sugar dehydrogenase YliI	-
KZ313_RS15200 (3156017)	3156017..3156400	-	384	WP_000497137.1	biofilm formation regulator BssR	-
KZ313_RS15205 (3156613)	3156613..3157938	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
KZ313_RS15210 (3158164)	3158164..3158550	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ313_RS15215 (3158540)	3158540..3158869	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
KZ313_RS15220 (3158939)	3158939..3160267	-	1329	WP_001550887.1	GGDEF domain-containing protein	-
KZ313_RS15225 (3160275)	3160275..3162623	-	2349	WP_001550886.1	EAL domain-containing protein	-
KZ313_RS15230 (3162801)	3162801..3163712	-	912	WP_001236042.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T211492 WP_000539521.1 NZ_CP080255:3158164-3158550 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T211492 NZ_CP104878:1836458-1836634 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATAAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT211492 WP_001280945.1 NZ_CP080255:3158540-3158869 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT211492 NZ_CP104878:c1836516-1836417 [Bacillus subtilis]
ATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTAT
GACTCTATTATAACATAATT

Structures

Toxin

• AlphaFold DB: A0A829GCT6