Detailed information of TA system TA021149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1983155..1983666
• Replicon: chromosome
• Accession: NC_006513
• Organism: Aromatoleum aromaticum EbN1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q5P3V9
• Locus tag: EB_RS09225
• Protein ID: WP_011237699.1
• Coordinates: 1983409..1983666 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: EB_RS09220
• Protein ID: WP_041646111.1
• Coordinates: 1983155..1983412 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB_RS09200	1978868..1979515	+	648	WP_011237693.1	orotate phosphoribosyltransferase	-
EB_RS09205	1979493..1980128	+	636	WP_011237694.1	DUF4124 domain-containing protein	-
EB_RS09210	1980221..1982305	+	2085	WP_011237696.1	molybdopterin oxidoreductase family protein	-
EB_RS09215	1982298..1983080	+	783	WP_011237697.1	NAD-dependent deacylase	-
EB_RS09220	1983155..1983412	+	258	WP_041646111.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EB_RS09225	1983409..1983666	+	258	WP_011237699.1	Txe/YoeB family addiction module toxin	Toxin
EB_RS09230	1983735..1984271	+	537	Protein_1834	transposase	-
EB_RS09235	1984580..1985257	-	678	Protein_1835	ISAs1-like element ISAzo29 family transposase	-
EB_RS24675	1985300..1985569	+	270	WP_162014362.1	hypothetical protein	-
EB_RS09240	1985493..1987052	+	1560	WP_041646113.1	IS21-like element ISAzo4 family transposase	-
EB_RS09245	1987075..1987809	+	735	WP_011236010.1	IS21-like element ISAzo4 family helper ATPase IstB	-
EB_RS09250	1988016..1988495	-	480	Protein_1839	ISAs1-like element ISAzo29 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10342.78 Da
• Isoelectric Point: 6.7243

>T21149 WP_011237699.1 NC_006513:1983409-1983666 [Aromatoleum aromaticum EbN1]
MRIIFHPQAWDDYLYWQQTDKQILKRVNALIRDIQRDPFDGIGKPEPLKFNLTAYWSRRIDDEHRIVYKVLDDEVIIAQA
RGHYE

Nucleotide

• Length: 258 bp

>T21149 NC_006513:1983409-1983666 [Aromatoleum aromaticum EbN1]
ATGAGGATTATCTTCCATCCCCAGGCCTGGGACGATTACCTCTACTGGCAGCAGACCGACAAGCAGATCCTCAAGCGGGT
CAATGCGCTGATCCGCGATATCCAACGCGATCCGTTCGACGGCATCGGCAAGCCCGAACCGTTGAAATTCAACCTCACCG
CCTACTGGTCGCGGCGCATCGACGACGAGCACCGCATCGTCTACAAAGTGCTGGACGACGAAGTCATCATTGCGCAGGCG
CGCGGGCACTACGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9921.35 Da
• Isoelectric Point: 4.8723

>AT21149 WP_041646111.1 NC_006513:1983155-1983412 [Aromatoleum aromaticum EbN1]
MRAITYTDARNNLASELDRVVNDCDVTIITRQKAEATVLMSMREYESLIETAHLLRNPKNAMRLMKAVDDIENRRNLIER
DLIEE

Nucleotide

• Length: 258 bp

>AT21149 NC_006513:1983155-1983412 [Aromatoleum aromaticum EbN1]
ATGCGAGCCATTACCTATACCGATGCGCGCAACAACCTCGCGTCCGAGCTTGACCGGGTGGTTAACGACTGCGACGTGAC
GATCATCACCCGCCAGAAGGCCGAGGCGACCGTACTGATGTCGATGCGCGAATACGAGTCGTTGATCGAAACCGCTCATC
TACTACGCAATCCGAAGAACGCGATGCGGCTGATGAAGGCCGTCGATGACATCGAGAACCGGCGCAATCTGATCGAGCGG
GACCTGATCGAGGAATGA

Structures

Toxin

• AlphaFold DB: Q5P3V9