Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 903826..904480 Replicon chromosome
Accession NZ_CP080255
Organism Escherichia coli strain SJC33

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag KZ313_RS04310 Protein ID WP_000244781.1
Coordinates 904073..904480 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag KZ313_RS04305 Protein ID WP_001564007.1
Coordinates 903826..904092 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ313_RS04285 (899914) 899914..901347 - 1434 WP_001513393.1 6-phospho-beta-glucosidase BglA -
KZ313_RS04290 (901392) 901392..901703 + 312 WP_001182951.1 N(4)-acetylcytidine aminohydrolase -
KZ313_RS04295 (901867) 901867..902526 + 660 WP_000250274.1 hemolysin III family protein -
KZ313_RS04300 (902603) 902603..903583 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
KZ313_RS04305 (903826) 903826..904092 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
KZ313_RS04310 (904073) 904073..904480 + 408 WP_000244781.1 protein YgfX Toxin
KZ313_RS04315 (904520) 904520..905041 - 522 WP_001055874.1 flavodoxin FldB -
KZ313_RS04320 (905153) 905153..906049 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KZ313_RS04325 (906074) 906074..906784 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZ313_RS04330 (906790) 906790..908523 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T211477 WP_000244781.1 NZ_CP080255:904073-904480 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T211477 NZ_CP104869:c4716460-4716050 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGTCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGTCTCGGCAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCACCC
CAATCGTATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT211477 WP_001564007.1 NZ_CP080255:903826-904092 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT211477 NZ_CP104869:c4716690-4716460 [Pseudomonas aeruginosa]
GTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCTTCCTGATGACGT
TAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGTGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCAGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References