Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2470731..2471369 Replicon chromosome
Accession NZ_CP080253
Organism Escherichia coli strain PC6

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KZX77_RS12130 Protein ID WP_000813794.1
Coordinates 2471193..2471369 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KZX77_RS12125 Protein ID WP_001270286.1
Coordinates 2470731..2471147 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX77_RS12105 (2465883) 2465883..2466824 - 942 WP_001251304.1 ABC transporter permease -
KZX77_RS12110 (2466825) 2466825..2467838 - 1014 WP_032358821.1 ABC transporter ATP-binding protein -
KZX77_RS12115 (2467856) 2467856..2469001 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KZX77_RS12120 (2469246) 2469246..2470652 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KZX77_RS12125 (2470731) 2470731..2471147 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KZX77_RS12130 (2471193) 2471193..2471369 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KZX77_RS12135 (2471591) 2471591..2471821 + 231 WP_000494244.1 YncJ family protein -
KZX77_RS12140 (2471913) 2471913..2473874 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KZX77_RS12145 (2473947) 2473947..2474483 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KZX77_RS12150 (2474575) 2474575..2475750 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T211466 WP_000813794.1 NZ_CP080253:c2471369-2471193 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T211466 NZ_CP104868:c147772-147491 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACTTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT211466 WP_001270286.1 NZ_CP080253:c2471147-2470731 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT211466 NZ_CP104868:c147996-147769 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References