Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2343630..2344156 Replicon chromosome
Accession NZ_CP080253
Organism Escherichia coli strain PC6

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KZX77_RS11535 Protein ID WP_000323025.1
Coordinates 2343869..2344156 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KZX77_RS11530 Protein ID WP_000534858.1
Coordinates 2343630..2343869 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX77_RS11500 (2338744) 2338744..2338995 + 252 Protein_2258 DUF977 family protein -
KZX77_RS11505 (2338992) 2338992..2339481 + 490 Protein_2259 class I SAM-dependent methyltransferase -
KZX77_RS11510 (2339959) 2339959..2340380 + 422 Protein_2260 hypothetical protein -
KZX77_RS11515 (2341036) 2341036..2342058 + 1023 Protein_2261 ISNCY family transposase -
KZX77_RS24120 (2342179) 2342179..2342328 + 150 WP_011443592.1 protein YdfW -
KZX77_RS11520 (2342765) 2342765..2343097 - 333 WP_001301033.1 FlxA-like family protein -
KZX77_RS11525 (2343300) 2343300..2343605 - 306 WP_001326990.1 protein YdfV -
KZX77_RS11530 (2343630) 2343630..2343869 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KZX77_RS11535 (2343869) 2343869..2344156 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KZX77_RS11540 (2344228) 2344228..2344383 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KZX77_RS11545 (2344600) 2344600..2344851 + 252 WP_000980994.1 protein Rem -
KZX77_RS11550 (2344918) 2344918..2345196 + 279 WP_012304870.1 hypothetical protein -
KZX77_RS11555 (2345198) 2345198..2346247 + 1050 WP_001265198.1 DUF968 domain-containing protein -
KZX77_RS11560 (2346261) 2346261..2347013 + 753 WP_061093371.1 antitermination protein -
KZX77_RS11565 (2347291) 2347291..2347380 - 90 WP_120795389.1 hypothetical protein -
KZX77_RS11570 (2347435) 2347435..2347647 - 213 WP_000087756.1 cold shock-like protein CspF -
KZX77_RS11575 (2347948) 2347948..2348079 + 132 Protein_2274 cold shock-like protein CspB -
KZX77_RS11580 (2348135) 2348135..2348832 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
KZX77_RS11585 (2348847) 2348847..2349149 + 303 Protein_2276 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2331093..2349149 18056
- flank IS/Tn - - 2348455..2348832 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T211464 WP_000323025.1 NZ_CP080253:2343869-2344156 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T211464 NZ_CP104867:c2575285-2574707 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
TCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGATAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT211464 WP_000534858.1 NZ_CP080253:2343630-2343869 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT211464 NZ_CP104867:c2575928-2575374 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTGGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References