Detailed information of TA system TA021145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1183986..1184569
• Replicon: chromosome
• Accession: NC_006513
• Organism: Aromatoleum aromaticum EbN1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q5P627
• Locus tag: EB_RS05600
• Protein ID: WP_011236958.1
• Coordinates: 1184186..1184569 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EB_RS05595
• Protein ID: WP_011236957.1
• Coordinates: 1183986..1184189 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB_RS24130	1180604..1181143	-	540	WP_011236950.1	sel1 repeat family protein	-
EB_RS05565	1181424..1181840	+	417	WP_011236951.1	pilin	-
EB_RS05570	1181958..1182230	+	273	Protein_1099	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EB_RS05575	1182291..1182563	+	273	WP_011236953.1	DUF1778 domain-containing protein	-
EB_RS05580	1182560..1183054	+	495	WP_011236954.1	GNAT family N-acetyltransferase	-
EB_RS05585	1183254..1183568	+	315	WP_011236955.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EB_RS05590	1183571..1183855	+	285	WP_011236956.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EB_RS05595	1183986..1184189	+	204	WP_011236957.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
EB_RS05600	1184186..1184569	+	384	WP_011236958.1	twitching motility protein PilT	Toxin
EB_RS05605	1184566..1185006	-	441	WP_157866582.1	GNAT family N-acetyltransferase	-
EB_RS05610	1185132..1185815	+	684	Protein_1107	IS21-like element ISAzo17 family transposase	-
EB_RS05615	1186050..1187618	+	1569	WP_011236587.1	IS21 family transposase	-
EB_RS05620	1187641..1188375	+	735	WP_011235973.1	IS21-like element ISAzo4 family helper ATPase IstB	-
EB_RS05625	1188579..1188992	+	414	Protein_1110	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14205.70 Da
• Isoelectric Point: 6.2186

>T21145 WP_011236958.1 NC_006513:1184186-1184569 [Aromatoleum aromaticum EbN1]
MKGVLVDTSIWVDHFRQRNDVLVGLLDLDLALTHPMVLVELACRTPPAPRVRTLGDIGLLQQTQQASLREVMDFIEREKL
YGLGCGLVDMVLLASTLITPGAELWTLDKRLAALSERFSVMHQPISR

Nucleotide

• Length: 384 bp

>T21145 NC_006513:1184186-1184569 [Aromatoleum aromaticum EbN1]
ATGAAAGGCGTCCTGGTCGACACATCGATATGGGTTGACCACTTCCGACAACGCAATGATGTCCTGGTGGGCTTGCTCGA
TCTGGACCTGGCGCTGACGCATCCGATGGTCCTGGTCGAACTTGCGTGCCGAACACCCCCTGCACCGCGAGTTCGGACAC
TCGGCGACATAGGACTGCTTCAACAGACGCAACAGGCGAGTTTGCGCGAGGTGATGGACTTCATTGAACGCGAAAAACTG
TATGGGCTTGGGTGCGGGCTGGTTGACATGGTTTTGTTGGCGTCAACGCTGATCACACCGGGCGCAGAGCTGTGGACGCT
GGACAAGCGCCTGGCCGCGCTGTCGGAACGGTTCAGCGTGATGCACCAACCGATCTCACGCTAG

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7567.67 Da
• Isoelectric Point: 5.0490

>AT21145 WP_011236957.1 NC_006513:1183986-1184189 [Aromatoleum aromaticum EbN1]
MRTTVTIDDDLYEKALEVADPAMDRADLFREAMKTFVRVQAAKRLAALGGTMPEMQDVPRRRGEPSQ

Nucleotide

• Length: 204 bp

>AT21145 NC_006513:1183986-1184189 [Aromatoleum aromaticum EbN1]
ATGAGAACGACTGTCACGATCGATGATGATCTGTACGAAAAGGCCCTGGAAGTGGCCGATCCGGCTATGGACAGGGCCGA
TCTCTTCCGCGAGGCGATGAAAACTTTCGTTCGGGTACAAGCCGCCAAGCGCCTTGCTGCGTTGGGGGGCACCATGCCGG
AGATGCAGGATGTGCCGCGACGGCGCGGCGAGCCCTCGCAATGA

Structures

Toxin

• AlphaFold DB: Q5P627