Detailed information of TA system TA211444

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2134062..2134576
• Replicon: chromosome
• Accession: NZ_CP080251
• Organism: Staphylococcus aureus strain NT_611

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: KZZ50_RS10625
• Protein ID: WP_217654535.1
• Coordinates: 2134062..2134271 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: W8UW13
• Locus tag: KZZ50_RS10630
• Protein ID: WP_000138932.1
• Coordinates: 2134283..2134576 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZZ50_RS10605 (2129570)	2129570..2130928	-	1359	WP_000611459.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
KZZ50_RS10610 (2130943)	2130943..2132013	-	1071	WP_000159631.1	D-alanine--D-alanine ligase	-
KZZ50_RS10615 (2132331)	2132331..2133533	+	1203	WP_001109936.1	FtsW/RodA/SpoVE family cell cycle protein	-
KZZ50_RS10620 (2133797)	2133797..2133934	-	138	WP_000828354.1	Lmo0850 family protein	-
KZZ50_RS10625 (2134062)	2134062..2134271	-	210	WP_217654535.1	heavy metal-associated domain-containing protein	Toxin
KZZ50_RS10630 (2134283)	2134283..2134576	-	294	WP_000138932.1	copper-sensing transcriptional repressor CsoR	Antitoxin
KZZ50_RS10635 (2134742)	2134742..2136226	+	1485	WP_000571549.1	cardiolipin synthase	-
KZZ50_RS10640 (2136254)	2136254..2136901	+	648	WP_001187630.1	HD domain-containing protein	-
KZZ50_RS10645 (2137367)	2137367..2138239	-	873	WP_000725802.1	membrane protein insertase YidC	-
KZZ50_RS10650 (2138325)	2138325..2138966	-	642	WP_000483153.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7834.76 Da
• Isoelectric Point: 3.9389

>T211444 WP_217654535.1 NZ_CP080251:c2134271-2134062 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVQQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T211444 NZ_CP104865:c4265844-4265089 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11197.82 Da
• Isoelectric Point: 6.2243

>AT211444 WP_000138932.1 NZ_CP080251:c2134576-2134283 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT211444 NZ_CP104865:c4266347-4265979 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Structures

Antitoxin

• AlphaFold DB: W8UW13