Detailed information of TA system TA211439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1917475..1918248
• Replicon: chromosome
• Accession: NZ_CP080251
• Organism: Staphylococcus aureus strain NT_611

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KZZ50_RS09315
• Protein ID: WP_000031107.1
• Coordinates: 1917475..1917624 (-)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KZZ50_RS09320
• Protein ID: WP_001251224.1
• Coordinates: 1917649..1918248 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZZ50_RS09300 (1913664)	1913664..1914485	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KZZ50_RS09305 (1914948)	1914948..1916333	-	1386	WP_000116234.1	class II fumarate hydratase	-
KZZ50_RS09310 (1916529)	1916529..1916924	-	396	WP_000901023.1	hypothetical protein	-
KZZ50_RS09315 (1917475)	1917475..1917624	-	150	WP_000031107.1	SAS053 family protein	Toxin
KZZ50_RS09320 (1917649)	1917649..1918248	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KZZ50_RS09325 (1918407)	1918407..1918877	-	471	WP_000181392.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KZZ50_RS09330 (1918882)	1918882..1920009	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KZZ50_RS09335 (1920160)	1920160..1920882	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KZZ50_RS09340 (1920875)	1920875..1922332	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5808.15 Da
• Isoelectric Point: 3.8962

>T211439 WP_000031107.1 NZ_CP080251:c1917624-1917475 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDS

Nucleotide

• Length: 150 bp

>T211439 NZ_CP104863:c4572581-4572294 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCGGGTGATCACCGCTATCTGGGGGACGGTATTTCCGAACTGCGTATCGATG
CAGGGCCGGGCTACCGCCTGTACTACACCCAGCGCGGCAGGCAGTTGCTGATTCTTTTGGTCGGAGGTGACAAAAGCTCA
CAGCAACGCGATATCGAAAAGGCCAGGGAGATTGCACGTGCCCTGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT211439 WP_001251224.1 NZ_CP080251:c1918248-1917649 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT211439 NZ_CP104863:c4572235-4571933 [Stenotrophomonas maltophilia]
ATGGCCACTAAGAAAAAAGTCGAACTCAAATCATTTGATGTGGCCGAACACCTTCGGACACCCGAAGAAATGGCAGCCTA
TCTCGACGCCTGCATCGAGGAAAGCGACGGCGATTCCGCGTTCATCGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAGG
GTATGAGCAAGGTTGCGCGCGCGGCGGGCCTGTCGCGCGAGAGTCTTTACCGCGCACTGTCCGGCGAACGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACCCGTGCCTTGGGTGTGCGCCTGCATGCCAGTGCCGTGTGA

Structures

Antitoxin

• AlphaFold DB: W8U4V4