Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1542983..1543771 | Replicon | chromosome |
| Accession | NZ_CP080251 | ||
| Organism | Staphylococcus aureus strain NT_611 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | KZZ50_RS07425 | Protein ID | WP_072519171.1 |
| Coordinates | 1543310..1543771 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | KZZ50_RS07420 | Protein ID | WP_000333630.1 |
| Coordinates | 1542983..1543297 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZZ50_RS07370 (1538524) | 1538524..1539690 | - | 1167 | WP_000762532.1 | DUF2800 domain-containing protein | - |
| KZZ50_RS07375 (1539687) | 1539687..1540049 | - | 363 | WP_000279445.1 | hypothetical protein | - |
| KZZ50_RS07380 (1540064) | 1540064..1540387 | - | 324 | WP_000174995.1 | hypothetical protein | - |
| KZZ50_RS07385 (1540466) | 1540466..1540627 | - | 162 | WP_015986189.1 | DUF1270 family protein | - |
| KZZ50_RS07390 (1540639) | 1540639..1540902 | - | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| KZZ50_RS07395 (1540927) | 1540927..1541142 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| KZZ50_RS07400 (1541197) | 1541197..1541562 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| KZZ50_RS07405 (1541531) | 1541531..1541776 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| KZZ50_RS07410 (1541805) | 1541805..1542581 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| KZZ50_RS07415 (1542595) | 1542595..1542831 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| KZZ50_RS07420 (1542983) | 1542983..1543297 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KZZ50_RS07425 (1543310) | 1543310..1543771 | + | 462 | WP_072519171.1 | toxin | Toxin |
| KZZ50_RS07430 (1543788) | 1543788..1544372 | + | 585 | WP_072519172.1 | hypothetical protein | - |
| KZZ50_RS07435 (1544602) | 1544602..1544748 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| KZZ50_RS07440 (1544745) | 1544745..1545359 | - | 615 | WP_000191457.1 | hypothetical protein | - |
| KZZ50_RS07445 (1545485) | 1545485..1546690 | + | 1206 | WP_000264747.1 | site-specific integrase | - |
| KZZ50_RS07450 (1546733) | 1546733..1548759 | - | 2027 | Protein_1464 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV | 1500698..1564327 | 63629 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18083.47 Da Isoelectric Point: 4.8017
>T211438 WP_072519171.1 NZ_CP080251:1543310-1543771 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEHYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEHYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T211438 NZ_CP104863:c4572235-4571933 [Stenotrophomonas maltophilia]
ATGGCCACTAAGAAAAAAGTCGAACTCAAATCATTTGATGTGGCCGAACACCTTCGGACACCCGAAGAAATGGCAGCCTA
TCTCGACGCCTGCATCGAGGAAAGCGACGGCGATTCCGCGTTCATCGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAGG
GTATGAGCAAGGTTGCGCGCGCGGCGGGCCTGTCGCGCGAGAGTCTTTACCGCGCACTGTCCGGCGAACGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACCCGTGCCTTGGGTGTGCGCCTGCATGCCAGTGCCGTGTGA
ATGGCCACTAAGAAAAAAGTCGAACTCAAATCATTTGATGTGGCCGAACACCTTCGGACACCCGAAGAAATGGCAGCCTA
TCTCGACGCCTGCATCGAGGAAAGCGACGGCGATTCCGCGTTCATCGCCAAGGCGCTCGGCGACATCGCGCGCGCTCAGG
GTATGAGCAAGGTTGCGCGCGCGGCGGGCCTGTCGCGCGAGAGTCTTTACCGCGCACTGTCCGGCGAACGCAGCCCCGAT
TTCGCCACCATCCTGAAGGTGACCCGTGCCTTGGGTGTGCGCCTGCATGCCAGTGCCGTGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT211438 WP_000333630.1 NZ_CP080251:1542983-1543297 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT211438 NZ_CP104863:c4572581-4572294 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCGGGTGATCACCGCTATCTGGGGGACGGTATTTCCGAACTGCGTATCGATG
CAGGGCCGGGCTACCGCCTGTACTACACCCAGCGCGGCAGGCAGTTGCTGATTCTTTTGGTCGGAGGTGACAAAAGCTCA
CAGCAACGCGATATCGAAAAGGCCAGGGAGATTGCACGTGCCCTGTGA
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCGGGTGATCACCGCTATCTGGGGGACGGTATTTCCGAACTGCGTATCGATG
CAGGGCCGGGCTACCGCCTGTACTACACCCAGCGCGGCAGGCAGTTGCTGATTCTTTTGGTCGGAGGTGACAAAAGCTCA
CAGCAACGCGATATCGAAAAGGCCAGGGAGATTGCACGTGCCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|