Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 841188..841665 Replicon chromosome
Accession NZ_CP080251
Organism Staphylococcus aureus strain NT_611

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KZZ50_RS04015 Protein ID WP_000052076.1
Coordinates 841188..841376 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KZZ50_RS04020 Protein ID WP_001059690.1
Coordinates 841405..841665 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZZ50_RS03985 (837182) 837182..837703 + 522 WP_000824482.1 hypothetical protein -
KZZ50_RS03990 (838044) 838044..838730 + 687 WP_000141557.1 thermonuclease family protein -
KZZ50_RS03995 (839087) 839087..839287 + 201 WP_001059082.1 cold-shock protein -
KZZ50_RS04000 (839779) 839779..839997 - 219 WP_000005886.1 hypothetical protein -
KZZ50_RS04005 (840059) 840059..840343 - 285 WP_001004399.1 hypothetical protein -
KZZ50_RS04010 (840431) 840431..841000 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KZZ50_RS04015 (841188) 841188..841376 - 189 WP_000052076.1 hypothetical protein Toxin
KZZ50_RS04020 (841405) 841405..841665 - 261 WP_001059690.1 hypothetical protein Antitoxin
KZZ50_RS04025 (842006) 842006..842209 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KZZ50_RS04030 (842206) 842206..842442 - 237 WP_000349581.1 hypothetical protein -
KZZ50_RS04035 (842667) 842667..843248 + 582 WP_001140693.1 histidine phosphatase family protein -
KZZ50_RS04040 (843321) 843321..843938 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KZZ50_RS04045 (844093) 844093..844587 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KZZ50_RS04050 (844986) 844986..845408 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KZZ50_RS04055 (845556) 845556..846272 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T211434 WP_000052076.1 NZ_CP080251:c841376-841188 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T211434 NZ_CP104861:4549155-4549442 [Pseudomonas fragi]
ATGACCTTTGATCTTGAGTTTGACCAGCGCGCCCTCAAGGAATGGCACAAACTCGCTGACACGGTCAGGCTGCAATTCAA
GAGCAAATTGTCAGAGGTGTTGCTCAACCCCCGCGTTGAAGCCAACCGGCTGCGCAAGCTGCCCGATTGTTACAAAATCA
AGTTGCGCAGCGCGGGTTACCGCTTGATCTATCAGGTCATTGATCAAGAGGTTGTGGTGTTCGTCGTCGCCGTTGACAAG
CGCGAACATCAGGCCGCGTATCGCAAGGCGCAAGACCGCTTGAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT211434 WP_001059690.1 NZ_CP080251:c841665-841405 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT211434 NZ_CP104861:4548926-4549165 [Pseudomonas fragi]
ATGGCCTCCATCAATATCCGCATCGACGATGAACTCAAAGCCCGCGCCTACAAGGAACTTGAGCGTTTGGGTGTCACCCC
CTCGGAACTGGTCCGCCAGGCATTGCAGTACGTAGCCGAACGCGGTCAACTGCCCTTTCGCCCCATGCTGGTGACAGAAG
AAGACGAAGCACTCATCAACACCGTGCGCGAACGCCTGGCAGCGCCGCAAAGGGTCAAGTTGACACTGGATGACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References