Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2655899..2656422 Replicon chromosome
Accession NZ_CP080249
Organism Staphylococcus aureus strain NV_1

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag KZW86_RS13505 Protein ID WP_000074049.1
Coordinates 2655899..2656165 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KZW86_RS13510 Protein ID WP_000587616.1
Coordinates 2656165..2656422 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW86_RS13485 (2651206) 2651206..2652393 - 1188 WP_000026189.1 MFS transporter -
KZW86_RS13490 (2652789) 2652789..2653565 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
KZW86_RS13495 (2653558) 2653558..2654220 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
KZW86_RS13500 (2654468) 2654468..2655544 - 1077 WP_001076673.1 M42 family metallopeptidase -
KZW86_RS13505 (2655899) 2655899..2656165 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
KZW86_RS13510 (2656165) 2656165..2656422 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZW86_RS13515 (2656781) 2656781..2657236 + 456 WP_000732076.1 DUF1307 domain-containing protein -
KZW86_RS13520 (2657404) 2657404..2658981 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
KZW86_RS13525 (2659176) 2659176..2659925 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T211432 WP_000074049.1 NZ_CP080249:c2656165-2655899 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T211432 NZ_CP104859:44209-44490 [Salmonella sp. 3C]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT211432 WP_000587616.1 NZ_CP080249:c2656422-2656165 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT211432 NZ_CP104859:43968-44219 [Salmonella sp. 3C]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References