Detailed information of TA system TA021143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1182291..1183054
• Replicon: chromosome
• Accession: NC_006513
• Organism: Aromatoleum aromaticum EbN1

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: Q5P631
• Locus tag: EB_RS05580
• Protein ID: WP_011236954.1
• Coordinates: 1182560..1183054 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: EB_RS05575
• Protein ID: WP_011236953.1
• Coordinates: 1182291..1182563 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB_RS05550	1177857..1178891	-	1035	WP_041646958.1	tellurite resistance/C4-dicarboxylate transporter family protein	-
EB_RS05555	1178930..1180441	-	1512	WP_011236949.1	PHB depolymerase family esterase	-
EB_RS24130	1180604..1181143	-	540	WP_011236950.1	sel1 repeat family protein	-
EB_RS05565	1181424..1181840	+	417	WP_011236951.1	pilin	-
EB_RS05570	1181958..1182230	+	273	Protein_1099	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EB_RS05575	1182291..1182563	+	273	WP_011236953.1	DUF1778 domain-containing protein	Antitoxin
EB_RS05580	1182560..1183054	+	495	WP_011236954.1	GNAT family N-acetyltransferase	Toxin
EB_RS05585	1183254..1183568	+	315	WP_011236955.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
EB_RS05590	1183571..1183855	+	285	WP_011236956.1	type II toxin-antitoxin system RelE/ParE family toxin	-
EB_RS05595	1183986..1184189	+	204	WP_011236957.1	type II toxin-antitoxin system VapB family antitoxin	-
EB_RS05600	1184186..1184569	+	384	WP_011236958.1	twitching motility protein PilT	-
EB_RS05605	1184566..1185006	-	441	WP_157866582.1	GNAT family N-acetyltransferase	-
EB_RS05610	1185132..1185815	+	684	Protein_1107	IS21-like element ISAzo17 family transposase	-
EB_RS05615	1186050..1187618	+	1569	WP_011236587.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1176180..1177559	1379

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (27-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-80)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17970.63 Da
• Isoelectric Point: 7.5570

>T21143 WP_011236954.1 NC_006513:1182560-1183054 [Aromatoleum aromaticum EbN1]
MSLQLSAPQPLAATHLLDEFASGETCLDEWLKRRALSNQLSGASRTFVVTDQEQHVFGYYAMAAGAVSHQMATGGVRRNM
PDPIPVMVLARLAIDDRVQGIKLGAALLQDAVNRAVAVSQNAGVRALLVHALHEHAKQFYEHYGFQESPQHPMTLMLRLN
TVKA

Nucleotide

• Length: 495 bp

>T21143 NC_006513:1182560-1183054 [Aromatoleum aromaticum EbN1]
ATGAGCTTGCAACTGAGCGCACCGCAACCCCTCGCTGCCACTCATCTTCTGGATGAATTTGCCAGCGGAGAAACGTGTCT
GGACGAATGGCTCAAGCGGCGGGCGCTGTCCAATCAGTTGAGTGGAGCCAGCCGCACATTCGTCGTCACGGATCAGGAGC
AGCACGTTTTCGGCTACTACGCGATGGCGGCCGGAGCGGTCTCGCACCAGATGGCGACGGGCGGCGTGCGGCGAAACATG
CCTGACCCCATTCCGGTGATGGTGCTGGCACGGCTCGCTATTGACGATCGTGTCCAGGGCATCAAACTCGGAGCCGCCCT
GCTTCAAGACGCTGTCAATCGGGCCGTGGCAGTGTCGCAGAACGCGGGCGTGCGAGCCTTGCTCGTTCATGCGCTTCACG
AGCATGCCAAGCAGTTTTACGAGCACTACGGTTTTCAGGAATCGCCACAGCACCCGATGACGCTGATGCTGCGCCTGAAC
ACCGTCAAGGCTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9838.30 Da
• Isoelectric Point: 5.0008

>AT21143 WP_011236953.1 NC_006513:1182291-1182563 [Aromatoleum aromaticum EbN1]
MRDAAINLRALPEQRDLIDHAASLLGKNRSDFMLEAACDRAQAVVLDQVFFGLDADKFKQFTAMLDAPPGPNPGLERLMA
VQAPWRTGAA

Nucleotide

• Length: 273 bp

>AT21143 NC_006513:1182291-1182563 [Aromatoleum aromaticum EbN1]
ATGCGTGACGCGGCCATCAACCTGCGGGCCTTGCCCGAGCAGCGTGACCTGATCGATCACGCTGCCAGCCTGTTGGGCAA
GAACCGTTCGGACTTCATGCTCGAAGCTGCTTGCGACCGAGCACAGGCCGTGGTGCTGGATCAGGTCTTTTTTGGCCTGG
ACGCCGACAAGTTCAAGCAGTTCACTGCCATGCTGGACGCACCCCCTGGACCAAATCCCGGGCTTGAACGCCTCATGGCC
GTGCAGGCGCCGTGGCGCACCGGCGCGGCATGA

Structures

Toxin

• AlphaFold DB: Q5P631