Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2264922..2265436 Replicon chromosome
Accession NZ_CP080249
Organism Staphylococcus aureus strain NV_1

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KZW86_RS11460 Protein ID WP_000581792.1
Coordinates 2264922..2265131 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KZW86_RS11465 Protein ID WP_000138932.1
Coordinates 2265143..2265436 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW86_RS11440 (2260430) 2260430..2261788 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KZW86_RS11445 (2261803) 2261803..2262873 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KZW86_RS11450 (2263191) 2263191..2264393 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KZW86_RS11455 (2264657) 2264657..2264794 - 138 WP_000828354.1 Lmo0850 family protein -
KZW86_RS11460 (2264922) 2264922..2265131 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KZW86_RS11465 (2265143) 2265143..2265436 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KZW86_RS11470 (2265602) 2265602..2267086 + 1485 WP_000571553.1 cardiolipin synthase -
KZW86_RS11475 (2267114) 2267114..2267761 + 648 WP_001187630.1 HD domain-containing protein -
KZW86_RS11480 (2268674) 2268674..2269546 - 873 WP_000725802.1 membrane protein insertase YidC -
KZW86_RS11485 (2269632) 2269632..2270273 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T211425 WP_000581792.1 NZ_CP080249:c2265131-2264922 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T211425 NZ_CP104858:2391455-2391763 [Salmonella sp. 3C]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT211425 WP_000138932.1 NZ_CP080249:c2265436-2265143 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT211425 NZ_CP104858:2391213-2391452 [Salmonella sp. 3C]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References