Detailed information of TA system TA211423

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 2182690..2183487
• Replicon: chromosome
• Accession: NZ_CP080249
• Organism: Staphylococcus aureus strain NV_1

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KZW86_RS11060
• Protein ID: WP_000525014.1
• Coordinates: 2183026..2183487 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: KZW86_RS11055
• Protein ID: WP_001260487.1
• Coordinates: 2182690..2183013 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW86_RS10985 (2177749)	2177749..2178507	-	759	WP_001003951.1	DUF1351 domain-containing protein	-
KZW86_RS10990 (2178518)	2178518..2178841	-	324	WP_000171560.1	hypothetical protein	-
KZW86_RS10995 (2178854)	2178854..2179465	-	612	WP_001105358.1	MBL fold metallo-hydrolase	-
KZW86_RS11000 (2179488)	2179488..2179724	-	237	WP_000802314.1	hypothetical protein	-
KZW86_RS11005 (2179732)	2179732..2179992	-	261	WP_000291082.1	DUF1108 family protein	-
KZW86_RS11010 (2180091)	2180091..2180252	-	162	WP_001285953.1	DUF1270 family protein	-
KZW86_RS11015 (2180249)	2180249..2180569	-	321	WP_001120202.1	DUF771 domain-containing protein	-
KZW86_RS11020 (2180720)	2180720..2180863	-	144	WP_000939498.1	hypothetical protein	-
KZW86_RS11025 (2180930)	2180930..2181152	+	223	Protein_2136	hypothetical protein	-
KZW86_RS11030 (2181139)	2181139..2181336	-	198	WP_031838117.1	hypothetical protein	-
KZW86_RS11035 (2181405)	2181405..2181617	+	213	WP_000362645.1	hypothetical protein	-
KZW86_RS11040 (2181658)	2181658..2181807	-	150	WP_000771849.1	hypothetical protein	-
KZW86_RS11045 (2181822)	2181822..2182265	-	444	WP_000435352.1	hypothetical protein	-
KZW86_RS11050 (2182278)	2182278..2182526	-	249	WP_000272856.1	helix-turn-helix transcriptional regulator	-
KZW86_RS11055 (2182690)	2182690..2183013	+	324	WP_001260487.1	helix-turn-helix transcriptional regulator	Antitoxin
KZW86_RS11060 (2183026)	2183026..2183487	+	462	WP_000525014.1	hypothetical protein	Toxin
KZW86_RS11065 (2183504)	2183504..2183950	+	447	WP_001226135.1	hypothetical protein	-
KZW86_RS11070 (2184019)	2184019..2184903	+	885	WP_001025527.1	hypothetical protein	-
KZW86_RS11075 (2185224)	2185224..2185577	+	354	WP_000528938.1	hypothetical protein	-
KZW86_RS11080 (2185676)	2185676..2185843	+	168	WP_001166555.1	hypothetical protein	-
KZW86_RS11085 (2186183)	2186183..2186548	+	366	WP_000440839.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KZW86_RS11090 (2186594)	2186594..2186887	+	294	WP_224397069.1	hypothetical protein	-
KZW86_RS11095 (2187049)	2187049..2188086	+	1038	WP_000857172.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2144898..2197154	52256

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T211423 WP_000525014.1 NZ_CP080249:2183026-2183487 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T211423 NZ_CP104858:2243180-2243671 [Salmonella sp. 3C]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT211423 WP_001260487.1 NZ_CP080249:2182690-2183013 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT211423 NZ_CP104858:2242890-2243183 [Salmonella sp. 3C]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCCGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36