Detailed information of TA system TA211415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2021723..2022499
• Replicon: chromosome
• Accession: NZ_CP080249
• Organism: Staphylococcus aureus strain NV_1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KZW86_RS10000
• Protein ID: WP_000031108.1
• Coordinates: 2021723..2021875 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: KZW86_RS10005
• Protein ID: WP_162649617.1
• Coordinates: 2021900..2022499 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW86_RS09985 (2017925)	2017925..2018746	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KZW86_RS09990 (2019199)	2019199..2020584	-	1386	WP_000116228.1	class II fumarate hydratase	-
KZW86_RS09995 (2020780)	2020780..2021175	-	396	WP_000901023.1	hypothetical protein	-
KZW86_RS10000 (2021723)	2021723..2021875	-	153	WP_000031108.1	SAS053 family protein	Toxin
KZW86_RS10005 (2021900)	2021900..2022499	-	600	WP_162649617.1	glucosamine-6-phosphate isomerase	Antitoxin
KZW86_RS10010 (2022658)	2022658..2023128	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KZW86_RS10015 (2023133)	2023133..2024260	-	1128	WP_234718522.1	tRNA epoxyqueuosine(34) reductase QueG	-
KZW86_RS10020 (2024411)	2024411..2025133	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KZW86_RS10025 (2025126)	2025126..2026583	-	1458	WP_000649908.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T211415 WP_000031108.1 NZ_CP080249:c2021875-2021723 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T211415 NZ_CP104858:755685-756212 [Salmonella sp. 3C]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22373.50 Da
• Isoelectric Point: 5.1445

>AT211415 WP_162649617.1 NZ_CP080249:c2022499-2021900 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHTVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT211415 NZ_CP104858:755398-755688 [Salmonella sp. 3C]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: X5E2E6