Detailed information of TA system TA021141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 910243..910822
• Replicon: chromosome
• Accession: NC_006513
• Organism: Aromatoleum aromaticum EbN1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EB_RS04310
• Protein ID: WP_197531874.1
• Coordinates: 910511..910822 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q5P6U3
• Locus tag: EB_RS04305
• Protein ID: WP_011236694.1
• Coordinates: 910243..910500 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EB_RS04285	906362..907108	-	747	WP_011236690.1	YdcF family protein	-
EB_RS04290	907127..907537	-	411	Protein_842	cupin domain-containing protein	-
EB_RS04295	907580..907918	-	339	WP_041645746.1	DUF2304 domain-containing protein	-
EB_RS04300	907915..909744	-	1830	WP_011236692.1	glycosyltransferase	-
EB_RS04305	910243..910500	+	258	WP_011236694.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EB_RS04310	910511..910822	+	312	WP_197531874.1	Txe/YoeB family addiction module toxin	Toxin
EB_RS04315	910794..912371	-	1578	WP_011236060.1	IS66-like element ISAzo15 family transposase	-
EB_RS04320	912468..912806	-	339	WP_011236696.1	IS66 family insertion sequence element accessory protein TnpB	-
EB_RS04325	912806..913132	-	327	WP_041645449.1	IS66 family insertion sequence hypothetical protein	-
EB_RS04330	913431..913751	-	321	WP_041645748.1	hypothetical protein	-
EB_RS04335	913738..914019	-	282	WP_041645751.1	hypothetical protein	-
EB_RS04340	914240..914419	+	180	WP_041645754.1	type II toxin-antitoxin system HicA family toxin	-
EB_RS04345	914431..914850	+	420	WP_041645757.1	type II toxin-antitoxin system HicB family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12061.01 Da
• Isoelectric Point: 9.1845

>T21141 WP_197531874.1 NC_006513:910511-910822 [Aromatoleum aromaticum EbN1]
MKLAWTLAAWEDYEYWQGQDRKALKRISALIKDCLRHPFEGIGKPEPLKENLSGFWSRRIDDTHRLVYCVDGQALAVIAC
RYHYQCKRPPLPRPLTLAQTLSF

Nucleotide

• Length: 312 bp

>T21141 NC_006513:910511-910822 [Aromatoleum aromaticum EbN1]
CTGAAACTGGCCTGGACCTTGGCCGCCTGGGAGGATTACGAATACTGGCAAGGCCAGGACCGCAAGGCACTCAAGCGCAT
CAGTGCCTTGATCAAGGACTGCCTGCGCCACCCCTTCGAGGGCATCGGTAAACCTGAGCCCTTGAAAGAAAACCTCTCAG
GCTTCTGGTCGCGCCGCATCGATGACACCCACCGGCTGGTTTACTGTGTCGATGGCCAGGCGCTGGCCGTCATCGCCTGT
CGCTACCACTACCAGTGTAAGCGTCCGCCGCTTCCACGCCCTCTTACGCTTGCGCAGACTCTTTCTTTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9551.76 Da
• Isoelectric Point: 5.6379

>AT21141 WP_011236694.1 NC_006513:910243-910500 [Aromatoleum aromaticum EbN1]
MRVVNFSEARNNLKNVIDQVIDDADYTVIARRDAPDAVVMSLDTFNGLMETVHLLKSPANAAHLARSIEQYRQGQVKQRD
LPNAD

Nucleotide

• Length: 258 bp

>AT21141 NC_006513:910243-910500 [Aromatoleum aromaticum EbN1]
ATGCGCGTGGTGAATTTCTCCGAGGCACGAAACAACCTCAAAAACGTGATCGATCAGGTCATCGACGATGCCGACTACAC
GGTCATCGCGCGTCGGGATGCGCCCGATGCGGTGGTGATGTCGCTGGACACCTTCAACGGCCTGATGGAGACGGTCCATC
TGCTCAAGTCGCCGGCCAACGCGGCGCATCTTGCGCGCTCCATCGAGCAGTACCGCCAGGGACAGGTGAAGCAGCGGGAC
CTGCCTAATGCCGATTGA

Structures

Antitoxin

• AlphaFold DB: Q5P6U3