Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 855317..855794 Replicon chromosome
Accession NZ_CP080249
Organism Staphylococcus aureus strain NV_1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KZW86_RS04080 Protein ID WP_000052076.1
Coordinates 855317..855505 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KZW86_RS04085 Protein ID WP_001059690.1
Coordinates 855534..855794 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW86_RS04050 (851311) 851311..851832 + 522 WP_234769155.1 hypothetical protein -
KZW86_RS04055 (852173) 852173..852859 + 687 WP_000141557.1 thermonuclease family protein -
KZW86_RS04060 (853216) 853216..853416 + 201 WP_001059082.1 cold-shock protein -
KZW86_RS04065 (853908) 853908..854126 - 219 WP_000005886.1 hypothetical protein -
KZW86_RS04070 (854188) 854188..854472 - 285 WP_001004399.1 hypothetical protein -
KZW86_RS04075 (854560) 854560..855129 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KZW86_RS04080 (855317) 855317..855505 - 189 WP_000052076.1 hypothetical protein Toxin
KZW86_RS04085 (855534) 855534..855794 - 261 WP_001059690.1 hypothetical protein Antitoxin
KZW86_RS04090 (856135) 856135..856338 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KZW86_RS04095 (856335) 856335..856571 - 237 WP_000349581.1 hypothetical protein -
KZW86_RS04100 (856796) 856796..857377 + 582 WP_001140693.1 histidine phosphatase family protein -
KZW86_RS04105 (857450) 857450..858067 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KZW86_RS04110 (858222) 858222..858716 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KZW86_RS04115 (859115) 859115..859537 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KZW86_RS04120 (859685) 859685..860401 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T211406 WP_000052076.1 NZ_CP080249:c855505-855317 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T211406 NZ_CP104856:c299261-299166 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT211406 WP_001059690.1 NZ_CP080249:c855794-855534 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT211406 NZ_CP104856:299066-299131 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References