Detailed information of TA system TA211403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3932329..3933143
• Replicon: chromosome
• Accession: NZ_CP080247
• Organism: Escherichia sp. TM-G17TGC

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: KY274_RS19145
• Protein ID: WP_001054376.1
• Coordinates: 3932329..3932586 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: KY274_RS19150
• Protein ID: WP_001309181.1
• Coordinates: 3932598..3933143 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KY274_RS19125 (3927617)	3927617..3928723	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
KY274_RS19130 (3928788)	3928788..3929768	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
KY274_RS22820 (3929878)	3929878..3930083	+	206	Protein_3742	HNH endonuclease	-
KY274_RS19135 (3930351)	3930351..3931591	-	1241	Protein_3743	helicase YjhR	-
KY274_RS22825 (3931707)	3931707..3931838	+	132	WP_001309182.1	hypothetical protein	-
KY274_RS19145 (3932329)	3932329..3932586	+	258	WP_001054376.1	YjhX family toxin	Toxin
KY274_RS19150 (3932598)	3932598..3933143	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
KY274_RS19155 (3933199)	3933199..3933945	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
KY274_RS19160 (3934114)	3934114..3934332	+	219	Protein_3748	hypothetical protein	-
KY274_RS19165 (3934370)	3934370..3934486	+	117	Protein_3749	VOC family protein	-
KY274_RS19170 (3934731)	3934731..3935852	+	1122	WP_000010829.1	M42 family metallopeptidase	-
KY274_RS19175 (3935849)	3935849..3936127	+	279	WP_000722973.1	PTS sugar transporter subunit IIB SgcB	-
KY274_RS19180 (3936139)	3936139..3937452	+	1314	WP_000460842.1	PTS sugar transporter subunit IIC SgcC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T211403 WP_001054376.1 NZ_CP080247:3932329-3932586 [Escherichia sp. TM-G17TGC]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T211403 NZ_CP104852:97630-98010 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT211403 WP_001309181.1 NZ_CP080247:3932598-3933143 [Escherichia sp. TM-G17TGC]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT211403 NZ_CP104852:97409-97630 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8