211382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1105887..1106554 Replicon chromosome
Accession NZ_CP080247
Organism Escherichia sp. TM-G17TGC

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag KY274_RS05305 Protein ID WP_001094400.1
Coordinates 1105887..1106216 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag KY274_RS05310 Protein ID WP_000072690.1
Coordinates 1106237..1106554 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KY274_RS05300 (1100943) 1100943..1105523 + 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -
KY274_RS05305 (1105887) 1105887..1106216 - 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
KY274_RS05310 (1106237) 1106237..1106554 - 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KY274_RS05315 (1106592) 1106592..1106792 - 201 WP_001395452.1 DUF987 domain-containing protein -
KY274_RS05320 (1106801) 1106801..1107283 - 483 WP_001407480.1 RadC family protein -
KY274_RS05325 (1107292) 1107292..1107750 - 459 WP_000211841.1 antirestriction protein -
KY274_RS05330 (1107853) 1107853..1108037 - 185 Protein_1040 DUF905 domain-containing protein -
KY274_RS05335 (1108648) 1108648..1110351 - 1704 WP_000896263.1 protein YfjW -
KY274_RS05340 (1110493) 1110493..1111502 + 1010 Protein_1042 arsenic transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - luxS 1057989..1127510 69521


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T211382 WP_001094400.1 NZ_CP080247:c1106216-1105887 [Escherichia sp. TM-G17TGC]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

>T211382 NZ_CP104851:340532-341059 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT211382 WP_000072690.1 NZ_CP080247:c1106554-1106237 [Escherichia sp. TM-G17TGC]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT211382 NZ_CP104851:340259-340525 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References