Detailed information of TA system TA021137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2696056..2696732
• Replicon: chromosome
• Accession: NC_006512
• Organism: Idiomarina loihiensis L2TR

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q5QV92
• Locus tag: IL_RS12900
• Protein ID: WP_011235741.1
• Coordinates: 2696283..2696732 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5QV93
• Locus tag: IL_RS12895
• Protein ID: WP_011235740.1
• Coordinates: 2696056..2696286 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL_RS12875	2691365..2692510	+	1146	WP_011235736.1	PepSY domain-containing protein	-
IL_RS12880	2692510..2692980	+	471	WP_011235737.1	hypothetical protein	-
IL_RS12885	2693053..2695194	+	2142	WP_011235738.1	TonB-dependent siderophore receptor	-
IL_RS12890	2695273..2695929	-	657	WP_011235739.1	epoxyqueuosine reductase QueH	-
IL_RS12895	2696056..2696286	+	231	WP_011235740.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
IL_RS12900	2696283..2696732	+	450	WP_011235741.1	type II toxin-antitoxin system VapC family toxin	Toxin
IL_RS12905	2696747..2697454	-	708	WP_011235742.1	ZIP family metal transporter	-
IL_RS12910	2697457..2698737	-	1281	WP_011235743.1	deoxyguanosinetriphosphate triphosphohydrolase family protein	-
IL_RS12915	2698942..2699235	+	294	WP_011235744.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IL_RS12920	2699247..2699570	+	324	WP_011235745.1	HigA family addiction module antidote protein	-
IL_RS12925	2699592..2700080	-	489	WP_011235746.1	hypothetical protein	-
IL_RS12930	2700272..2700940	+	669	WP_011235747.1	hypothetical protein	-
IL_RS12935	2700937..2701335	-	399	WP_011235748.1	type II toxin-antitoxin system YafO family toxin	-
IL_RS12940	2701332..2701625	-	294	WP_011235749.1	type I toxin-antitoxin system antitoxin YafN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 17104.45 Da
• Isoelectric Point: 6.9570

>T21137 WP_011235741.1 NC_006512:2696283-2696732 [Idiomarina loihiensis L2TR]
MNLRYMLDTNICIYIMKNRPTYLAPIFDEHSRELCISSVTVMELQYGVENSQQRTTNADKLDSFLARLKILNYDTDAAYH
TALIRHKLKQEGTPIGSYDQMIAGHARCHGLTVVTNNTKEFERVPGLITENWLQQPPQSSINEPTPAYR

Nucleotide

• Length: 450 bp

>T21137 NC_006512:2696283-2696732 [Idiomarina loihiensis L2TR]
ATGAACTTGCGTTATATGCTCGATACGAATATCTGCATCTATATTATGAAAAATAGGCCAACATATTTAGCCCCTATTTT
TGATGAGCACTCGCGCGAGCTCTGCATCAGTTCAGTTACAGTAATGGAACTGCAATATGGTGTCGAAAACTCGCAGCAAC
GTACAACTAATGCCGACAAACTCGACAGCTTTTTGGCTCGTTTAAAAATATTAAATTACGATACTGACGCGGCTTATCAC
ACAGCACTTATTCGTCACAAACTGAAACAGGAAGGCACACCAATTGGTTCCTATGATCAGATGATAGCTGGCCATGCCCG
ATGCCATGGACTCACGGTTGTTACCAATAACACCAAAGAATTTGAACGAGTTCCCGGACTTATTACCGAAAACTGGCTGC
AACAACCACCGCAATCATCAATCAATGAGCCAACTCCGGCCTATCGTTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8647.69 Da
• Isoelectric Point: 4.3575

>AT21137 WP_011235740.1 NC_006512:2696056-2696286 [Idiomarina loihiensis L2TR]
MTKTSLFKSNKTQAVRLPKDVAFSEDVKEVEVLVVGESRIITPAKTSWASWFTGESASDDFMIEREQPEEQERDPL

Nucleotide

• Length: 231 bp

>AT21137 NC_006512:2696056-2696286 [Idiomarina loihiensis L2TR]
ATGACTAAAACAAGCTTATTTAAAAGTAACAAAACTCAAGCTGTCCGATTACCCAAAGACGTTGCCTTTTCCGAAGACGT
TAAAGAGGTGGAAGTTTTAGTCGTTGGTGAAAGCCGAATTATTACCCCGGCCAAAACAAGCTGGGCATCCTGGTTTACTG
GTGAATCCGCAAGTGATGACTTTATGATTGAACGCGAGCAGCCCGAGGAGCAGGAGCGTGACCCGCTATGA

Structures

Toxin

• AlphaFold DB: Q5QV92

Antitoxin

• AlphaFold DB: Q5QV93