Detailed information of TA system TA021135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1386628..1387181
• Replicon: chromosome
• Accession: NC_006512
• Organism: Idiomarina loihiensis L2TR

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5QYX8
• Locus tag: IL_RS06625
• Protein ID: WP_011234535.1
• Coordinates: 1386628..1386921 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q5QYX7
• Locus tag: IL_RS06630
• Protein ID: WP_011234536.1
• Coordinates: 1386909..1387181 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL_RS06610	1383474..1383650	+	177	WP_011234532.1	ribosome modulation factor	-
IL_RS06615	1383724..1384236	-	513	WP_011234533.1	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA	-
IL_RS06620	1384319..1386235	-	1917	WP_011234534.1	Lon protease family protein	-
IL_RS06625	1386628..1386921	-	294	WP_011234535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IL_RS06630	1386909..1387181	-	273	WP_011234536.1	CopG family ribbon-helix-helix protein	Antitoxin
IL_RS06635	1387680..1388591	-	912	WP_011234537.1	LysR family transcriptional regulator	-
IL_RS06640	1388706..1389266	+	561	WP_011234538.1	NAD(P)H-dependent oxidoreductase	-
IL_RS06645	1389284..1389475	-	192	WP_011234539.1	CPXCG motif-containing cysteine-rich protein	-
IL_RS06650	1389578..1390657	+	1080	WP_011234540.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11110.82 Da
• Isoelectric Point: 7.2006

>T21135 WP_011234535.1 NC_006512:c1386921-1386628 [Idiomarina loihiensis L2TR]
VSQVIWSPAALADVKRLHDFLRDKDPIVARKAVKSIRQNVLILAGQPEIGRPLDDMPIEFREWLIDFGQSGYVALYRYDG
FETIILAVRHQKEVGYS

Nucleotide

• Length: 294 bp

>T21135 NC_006512:c1386921-1386628 [Idiomarina loihiensis L2TR]
GTGTCACAAGTAATTTGGTCCCCGGCCGCTTTAGCGGACGTGAAACGTCTGCATGATTTTTTACGAGATAAAGACCCGAT
AGTGGCCCGTAAGGCCGTCAAAAGCATTCGCCAAAACGTCCTTATTTTGGCTGGCCAACCCGAGATTGGCCGCCCGCTGG
ATGATATGCCCATTGAATTTAGAGAGTGGCTCATTGATTTTGGCCAGAGCGGTTATGTTGCTCTCTACCGTTACGATGGC
TTTGAAACGATCATCCTTGCGGTGCGACACCAAAAGGAAGTTGGCTATTCGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10633.83 Da
• Isoelectric Point: 5.9830

>AT21135 WP_011234536.1 NC_006512:c1387181-1386909 [Idiomarina loihiensis L2TR]
MATSVKLNDDMKKRVQNLANVRHRSSHWIMRQAIQDYVEREEKREAFKQDALRAWEDYQHNGLHLTAEEADEWLAKLESG
DDAELPTCHK

Nucleotide

• Length: 273 bp

>AT21135 NC_006512:c1387181-1386909 [Idiomarina loihiensis L2TR]
ATGGCAACATCCGTAAAACTGAATGACGACATGAAAAAACGCGTGCAAAATCTGGCGAACGTCCGGCACCGTTCCTCACA
CTGGATCATGCGTCAGGCGATCCAGGATTATGTTGAACGTGAAGAAAAACGGGAAGCGTTTAAACAGGACGCACTTCGCG
CCTGGGAGGATTATCAGCATAATGGTTTGCATTTGACGGCAGAGGAAGCTGATGAATGGTTAGCCAAACTTGAATCGGGT
GACGATGCTGAGCTGCCGACGTGTCACAAGTAA

Structures

Toxin

• AlphaFold DB: Q5QYX8

Antitoxin

• AlphaFold DB: Q5QYX7