Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 100838..101484 Replicon plasmid p29334-2
Accession NZ_CP080245
Organism Polymorphobacter sp. PAMC 29334

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZX46_RS21660 Protein ID WP_219777365.1
Coordinates 100838..101227 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZX46_RS21665 Protein ID WP_219777366.1
Coordinates 101227..101484 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX46_RS21635 (KZX46_21630) 96008..96298 - 291 WP_219777360.1 helix-turn-helix transcriptional regulator -
KZX46_RS21640 (KZX46_21635) 96315..97574 - 1260 WP_219777361.1 tyrosine-type recombinase/integrase -
KZX46_RS21645 (KZX46_21640) 97571..98950 - 1380 WP_219777362.1 site-specific integrase -
KZX46_RS21650 (KZX46_21645) 99981..100373 - 393 WP_219777363.1 hypothetical protein -
KZX46_RS21655 (KZX46_21650) 100656..100841 - 186 Protein_96 hypothetical protein -
KZX46_RS21660 (KZX46_21655) 100838..101227 - 390 WP_219777365.1 type II toxin-antitoxin system VapC family toxin Toxin
KZX46_RS21665 (KZX46_21660) 101227..101484 - 258 WP_219777366.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KZX46_RS21670 (KZX46_21665) 101863..102522 - 660 WP_219777367.1 neutral zinc metallopeptidase -
KZX46_RS21675 (KZX46_21670) 102759..103205 - 447 WP_219777368.1 nickel-responsive transcriptional regulator NikR -
KZX46_RS23285 103262..104092 - 831 WP_255615653.1 hypothetical protein -
KZX46_RS23290 104117..105415 + 1299 WP_255615654.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..291297 291297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-84)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13956.96 Da        Isoelectric Point: 5.7559

>T211347 WP_219777365.1 NZ_CP080245:c101227-100838 [Polymorphobacter sp. PAMC 29334]
MVIDSSALMAILRREPEEQDFRKAIKLAASRLLSASTRVEVGIVALGRAGEAGLEQLQALLDTLRVETVPVSADHADLAI
DAFRRFGKGRHPAGLNFGDCFSYALAKATGEPLLFKGQDFSQTDIERAV

Download         Length: 390 bp

>T211347 NZ_CP104846:c3198582-3198331 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9569.69 Da        Isoelectric Point: 4.5393

>AT211347 WP_219777366.1 NZ_CP080245:c101484-101227 [Polymorphobacter sp. PAMC 29334]
MALSLKDRETDSLARQVASLTGETLTEAVRGALRLRLRDEQLKRGERPWDDAAIDAIIERFNALPVLDHRTDDDILGYDE
HGLPS

Download         Length: 258 bp

>AT211347 NZ_CP104846:c3198334-3198080 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References