Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2714663..2715180 Replicon chromosome
Accession NZ_CP080243
Organism Polymorphobacter sp. PAMC 29334

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KZX46_RS16590 Protein ID WP_219774897.1
Coordinates 2714663..2714929 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KZX46_RS16595 Protein ID WP_219774898.1
Coordinates 2714926..2715180 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX46_RS16565 (KZX46_16555) 2709917..2710456 + 540 WP_219774893.1 hypothetical protein -
KZX46_RS16570 (KZX46_16560) 2710558..2710806 - 249 WP_219774894.1 hypothetical protein -
KZX46_RS16575 (KZX46_16565) 2710995..2711753 + 759 WP_219774895.1 sterol desaturase family protein -
KZX46_RS16580 (KZX46_16570) 2711946..2713808 + 1863 WP_219774896.1 phosphomethylpyrimidine synthase ThiC -
KZX46_RS16585 (KZX46_16575) 2713845..2714612 + 768 WP_226896005.1 DUF4145 domain-containing protein -
KZX46_RS16590 (KZX46_16580) 2714663..2714929 - 267 WP_219774897.1 Txe/YoeB family addiction module toxin Toxin
KZX46_RS16595 (KZX46_16585) 2714926..2715180 - 255 WP_219774898.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KZX46_RS16600 (KZX46_16590) 2715222..2715788 - 567 WP_219774899.1 type II toxin-antitoxin system ParD family antitoxin -
KZX46_RS16605 (KZX46_16595) 2715949..2717181 + 1233 WP_219774900.1 hypothetical protein -
KZX46_RS16610 (KZX46_16600) 2717512..2718723 + 1212 WP_219774901.1 autotransporter outer membrane beta-barrel domain-containing protein -
KZX46_RS16615 (KZX46_16605) 2718848..2720101 - 1254 WP_216707903.1 ATP-dependent Clp protease ATP-binding subunit ClpX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10408.86 Da        Isoelectric Point: 9.5776

>T211346 WP_219774897.1 NZ_CP080243:c2714929-2714663 [Polymorphobacter sp. PAMC 29334]
VKVTFDADAWTEYLTWIDEDRKVLARINALIAECRRDPFRGTGKPEPLKRNLTGWWSRRITTEHRLVYRVRGTGEGQALE
VLSCRYHY

Download         Length: 267 bp

>T211346 NZ_CP104846:c3198334-3198080 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9229.55 Da        Isoelectric Point: 4.5659

>AT211346 WP_219774898.1 NZ_CP080243:c2715180-2714926 [Polymorphobacter sp. PAMC 29334]
MYALSFSETRANLKAVMDRVVADRAPVVITRQRGESVVMVAQSDWEAMEETLYLLSSPANAKHLMDGIARLDAGLGEGHE
LIEP

Download         Length: 255 bp

>AT211346 NZ_CP104846:c3198582-3198331 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References