Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 454488..455034 Replicon chromosome
Accession NZ_CP080243
Organism Polymorphobacter sp. PAMC 29334

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KZX46_RS06000 Protein ID WP_219775884.1
Coordinates 454738..455034 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KZX46_RS05995 Protein ID WP_219775883.1
Coordinates 454488..454733 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX46_RS05975 (KZX46_05970) 449622..452036 + 2415 WP_226896126.1 PBP1A family penicillin-binding protein -
KZX46_RS05980 (KZX46_05975) 452179..452934 + 756 WP_219775880.1 hypothetical protein -
KZX46_RS05985 (KZX46_05980) 452962..454090 + 1129 WP_219775881.1 peptide chain release factor 2 -
KZX46_RS05990 (KZX46_05985) 454087..454428 - 342 WP_219775882.1 energy transducer TonB -
KZX46_RS05995 (KZX46_05990) 454488..454733 + 246 WP_219775883.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KZX46_RS06000 (KZX46_05995) 454738..455034 + 297 WP_219775884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZX46_RS06005 (KZX46_06000) 455092..456357 + 1266 WP_219775885.1 amidohydrolase family protein -
KZX46_RS06010 (KZX46_06005) 456594..457358 + 765 WP_226896127.1 PEPxxWA-CTERM sorting domain-containing protein -
KZX46_RS06015 (KZX46_06010) 457422..458285 - 864 WP_219775886.1 transglutaminase family protein -
KZX46_RS06020 (KZX46_06015) 458291..459172 - 882 WP_219775887.1 transglutaminase family protein -
KZX46_RS06025 (KZX46_06020) 459187..459954 + 768 WP_219775888.1 N-formylglutamate amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(6-62)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11024.48 Da        Isoelectric Point: 5.1259

>T211345 WP_219775884.1 NZ_CP080243:454738-455034 [Polymorphobacter sp. PAMC 29334]
VPVYRLSRAADDDIDAIFFAGIEMFGVAHAETYYAGLSAALAFLADNPFAARLRREIEPPVRAWRHKAHLIVYEVDTDGI
LVLRVRHGREDWLGSGEE

Download         Length: 297 bp

>T211345 NZ_CP104846:3187173-3187547 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9132.39 Da        Isoelectric Point: 10.1884

>AT211345 WP_219775883.1 NZ_CP080243:454488-454733 [Polymorphobacter sp. PAMC 29334]
MATMNISLPDPMKQWIEAQATTGRYSNVSDFVRDLVRREQERREKIAAIQRLVDEARASGVGERSMADIREGVLRRAGVT
A

Download         Length: 246 bp

>AT211345 NZ_CP104846:3186716-3187084 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References