Detailed information of TA system TA211344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 516796..517437
• Replicon: plasmid p29334-1
• Accession: NZ_CP080242
• Organism: Polymorphobacter sp. PAMC 29334

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KZX46_RS02395
• Protein ID: WP_226895819.1
• Coordinates: 517180..517437 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KZX46_RS02390
• Protein ID: WP_219773756.1
• Coordinates: 516796..517053 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX46_RS02365 (KZX46_02360)	512222..512587	-	366	WP_219773751.1	hypothetical protein	-
KZX46_RS02370 (KZX46_02365)	512589..513230	-	642	WP_219773752.1	hypothetical protein	-
KZX46_RS02375 (KZX46_02370)	513944..515191	-	1248	WP_219773753.1	hypothetical protein	-
KZX46_RS02380 (KZX46_02375)	515828..516064	+	237	WP_219773754.1	type II toxin-antitoxin system VapB family antitoxin	-
KZX46_RS02385 (KZX46_02380)	516061..516459	+	399	WP_219773755.1	type II toxin-antitoxin system VapC family toxin	-
KZX46_RS02390 (KZX46_02385)	516796..517053	+	258	WP_219773756.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KZX46_RS02395 (KZX46_02390)	517180..517437	+	258	WP_226895819.1	type II toxin-antitoxin system VapC family toxin	Toxin
KZX46_RS02400 (KZX46_02395)	517570..517788	-	219	Protein_481	BrnA antitoxin family protein	-
KZX46_RS02405 (KZX46_02400)	517855..518043	-	189	WP_219773759.1	BrnT family toxin	-
KZX46_RS02410 (KZX46_02405)	518186..518644	+	459	WP_219773760.1	hypothetical protein	-
KZX46_RS02415 (KZX46_02410)	518870..519145	-	276	WP_219773761.1	hypothetical protein	-
KZX46_RS02420 (KZX46_02415)	519446..519844	-	399	WP_219773762.1	hypothetical protein	-
KZX46_RS02425 (KZX46_02420)	520080..520826	-	747	WP_226895820.1	ERAP1-like C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..841599	841599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (12-81)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9134.40 Da
• Isoelectric Point: 6.2084

>T211344 WP_226895819.1 NZ_CP080242:517180-517437 [Polymorphobacter sp. PAMC 29334]
MSLSRAGEAGLEQLQALLDTLKIETVPVSANHASLAIDAFRRFGKGRHSAGLNFGDCFLYALAKATGEPVLFKGEVFSHT
DIEQV

Nucleotide

• Length: 258 bp

>T211344 NZ_CP104846:c2926675-2926573 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9715.85 Da
• Isoelectric Point: 4.4237

>AT211344 WP_219773756.1 NZ_CP080242:516796-517053 [Polymorphobacter sp. PAMC 29334]
MALSVKDRETDSLARQVTSMTGETLTEAVRGALRLRLRDEQLKRGERPWDDQAIDAILERFNALPLLDQRFDDEILGYDE
HGLSS

Nucleotide

• Length: 258 bp

>AT211344 NZ_CP104846:2926535-2926803 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT