Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 515828..516459 Replicon plasmid p29334-1
Accession NZ_CP080242
Organism Polymorphobacter sp. PAMC 29334

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZX46_RS02385 Protein ID WP_219773755.1
Coordinates 516061..516459 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZX46_RS02380 Protein ID WP_219773754.1
Coordinates 515828..516064 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX46_RS02365 (KZX46_02360) 512222..512587 - 366 WP_219773751.1 hypothetical protein -
KZX46_RS02370 (KZX46_02365) 512589..513230 - 642 WP_219773752.1 hypothetical protein -
KZX46_RS02375 (KZX46_02370) 513944..515191 - 1248 WP_219773753.1 hypothetical protein -
KZX46_RS02380 (KZX46_02375) 515828..516064 + 237 WP_219773754.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KZX46_RS02385 (KZX46_02380) 516061..516459 + 399 WP_219773755.1 type II toxin-antitoxin system VapC family toxin Toxin
KZX46_RS02390 (KZX46_02385) 516796..517053 + 258 WP_219773756.1 type II toxin-antitoxin system VapB family antitoxin -
KZX46_RS02395 (KZX46_02390) 517180..517437 + 258 WP_226895819.1 type II toxin-antitoxin system VapC family toxin -
KZX46_RS02400 (KZX46_02395) 517570..517788 - 219 Protein_481 BrnA antitoxin family protein -
KZX46_RS02405 (KZX46_02400) 517855..518043 - 189 WP_219773759.1 BrnT family toxin -
KZX46_RS02410 (KZX46_02405) 518186..518644 + 459 WP_219773760.1 hypothetical protein -
KZX46_RS02415 (KZX46_02410) 518870..519145 - 276 WP_219773761.1 hypothetical protein -
KZX46_RS02420 (KZX46_02415) 519446..519844 - 399 WP_219773762.1 hypothetical protein -
KZX46_RS02425 (KZX46_02420) 520080..520826 - 747 WP_226895820.1 ERAP1-like C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..841599 841599


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14476.61 Da        Isoelectric Point: 5.1771

>T211343 WP_219773755.1 NZ_CP080242:516061-516459 [Polymorphobacter sp. PAMC 29334]
VTFLLDTNAVIAVLRNPASTVALRLRRQSPEDVAISVVVLHELYWGAYRSARVEHNLAQVDVLAFPVLDLDLDDAREAGR
LRAELAAVGLRIGGYDLLIAGQARARGLIVVTANTREFERVVGLNFEDWAAV

Download         Length: 399 bp

>T211343 NZ_CP104846:c2645701-2644379 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8662.80 Da        Isoelectric Point: 4.9611

>AT211343 WP_219773754.1 NZ_CP080242:515828-516064 [Polymorphobacter sp. PAMC 29334]
MDTAKLFWTGRSQAVRLPRAYRIDGDAVRIRRAGAAVVLEPLPVSWAWLDGLQPVDADFFEDGRDQPPPQPRAAFDAA

Download         Length: 237 bp

>AT211343 NZ_CP104846:c2645967-2645701 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References