Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 27362..27927 Replicon plasmid p2-ED002
Accession NZ_CP080240
Organism Vibrio sp. ED002

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ITG12_RS27170 Protein ID WP_248875240.1
Coordinates 27640..27927 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ITG12_RS27165 Protein ID WP_248875238.1
Coordinates 27362..27643 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITG12_RS27135 (ITG12_27060) 22646..23134 - 489 WP_248875232.1 mobile mystery protein A -
ITG12_RS27760 23651..23983 - 333 WP_283102975.1 hypothetical protein -
ITG12_RS27140 (ITG12_27070) 24017..24925 + 909 WP_283102976.1 MFS transporter -
ITG12_RS27145 (ITG12_27075) 25378..26025 + 648 WP_248875234.1 recombinase family protein -
ITG12_RS27150 (ITG12_27080) 26520..26648 + 129 WP_248875264.1 DUF3265 domain-containing protein -
ITG12_RS27155 (ITG12_27085) 26732..27142 + 411 WP_248875236.1 GNAT family N-acetyltransferase -
ITG12_RS27160 (ITG12_27090) 27161..27271 + 111 WP_248875266.1 DUF3265 domain-containing protein -
ITG12_RS27165 (ITG12_27095) 27362..27643 + 282 WP_248875238.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ITG12_RS27170 (ITG12_27100) 27640..27927 + 288 WP_248875240.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ITG12_RS27175 (ITG12_27105) 28528..29871 - 1344 WP_248875242.1 ISNCY family transposase -
ITG12_RS27180 (ITG12_27110) 30312..30593 - 282 WP_248875244.1 hypothetical protein -
ITG12_RS27185 (ITG12_27115) 30648..31412 - 765 WP_248875246.1 ParA family protein -
ITG12_RS27190 (ITG12_27120) 31594..32532 + 939 WP_248875248.1 Rpn family recombination-promoting nuclease/putative transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pilW 1..93724 93724
- inside Integron - - 26536..28323 1787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11084.74 Da        Isoelectric Point: 5.1098

>T211342 WP_248875240.1 NZ_CP080240:27640-27927 [Vibrio sp. ED002]
MKVVWSPLALQKLGDAAEFISWDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQMLSEDDV

Download         Length: 288 bp

>T211342 NZ_CP104846:c2336519-2336412 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10384.92 Da        Isoelectric Point: 7.0141

>AT211342 WP_248875238.1 NZ_CP080240:27362-27643 [Vibrio sp. ED002]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
TDARAQVLGRIKK

Download         Length: 282 bp

>AT211342 NZ_CP104846:2336567-2336633 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References