Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 263274..263833 | Replicon | chromosome |
| Accession | NZ_CP080238 | ||
| Organism | Vibrio sp. ED002 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | ITG12_RS01615 | Protein ID | WP_203343951.1 |
| Coordinates | 263274..263552 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | ITG12_RS01620 | Protein ID | WP_005398409.1 |
| Coordinates | 263549..263833 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ITG12_RS01560 (ITG12_01495) | 258506..258598 | + | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01565 (ITG12_01500) | 258725..259642 | + | 918 | WP_038882244.1 | hypothetical protein | - |
| ITG12_RS01570 (ITG12_01505) | 259657..259749 | + | 93 | WP_075111285.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01575 (ITG12_01510) | 260369..260539 | + | 171 | WP_173400293.1 | hypothetical protein | - |
| ITG12_RS01580 (ITG12_01515) | 260553..260810 | + | 258 | WP_029857974.1 | hypothetical protein | - |
| ITG12_RS01585 (ITG12_01520) | 260835..260927 | + | 93 | WP_079857915.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01590 (ITG12_01525) | 260968..261819 | + | 852 | WP_038882245.1 | hypothetical protein | - |
| ITG12_RS01595 (ITG12_01530) | 261986..262342 | + | 357 | WP_038882247.1 | hypothetical protein | - |
| ITG12_RS01600 (ITG12_01535) | 262357..262449 | + | 93 | WP_193788566.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01605 (ITG12_01540) | 262487..263092 | + | 606 | WP_038882248.1 | hypothetical protein | - |
| ITG12_RS01610 (ITG12_01545) | 263153..263245 | + | 93 | WP_193788567.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01615 (ITG12_01550) | 263274..263552 | - | 279 | WP_203343951.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ITG12_RS01620 (ITG12_01555) | 263549..263833 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| ITG12_RS01625 | 263910..264001 | + | 92 | Protein_317 | DUF3265 domain-containing protein | - |
| ITG12_RS01630 (ITG12_01565) | 264053..264406 | + | 354 | WP_248873470.1 | DUF6404 family protein | - |
| ITG12_RS01635 (ITG12_01570) | 264437..264526 | + | 90 | WP_079866497.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01640 (ITG12_01575) | 264560..265036 | + | 477 | WP_038882495.1 | GNAT family N-acetyltransferase | - |
| ITG12_RS01645 (ITG12_01580) | 265054..265143 | + | 90 | WP_077345960.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01650 (ITG12_01585) | 265287..266525 | + | 1239 | WP_248873140.1 | IS256-like element ISVa19 family transposase | - |
| ITG12_RS01655 (ITG12_01590) | 267615..267704 | + | 90 | WP_072829120.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01660 (ITG12_01595) | 268122..268250 | + | 129 | WP_099098883.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01665 (ITG12_01600) | 268435..268650 | + | 216 | WP_227741164.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 160161..277551 | 117390 | |
| - | flank | IS/Tn | - | - | 265287..266525 | 1238 | |
| - | inside | Integron | - | - | 184077..270640 | 86563 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10919.63 Da Isoelectric Point: 4.3535
>T211341 WP_203343951.1 NZ_CP080238:c263552-263274 [Vibrio sp. ED002]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPEAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T211341 NZ_CP104846:1485048-1485350 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT211341 WP_005398409.1 NZ_CP080238:c263833-263549 [Vibrio sp. ED002]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT211341 NZ_CP104846:1485386-1485727 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|